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Gastroenterology:小儿肠道疾病的抗体检测

2017-04-30 zhangfan MedSci原创

抗体检测是一种有效的儿科肠道疾病活检替代方法

长期以来腹腔肠道疾病的诊断依据包括临床,遗传,血清学和十二指肠形态特征。近日研究发现,对于抗组织转谷氨酰胺酶免疫球蛋白浓度(IgA TTG)超过正常值上限(ULN)10倍的患儿,免疫检测可代替活检分析,测定IgA-TTG以及总脱酰氨基醇溶蛋白抗体含量(IgG DGL,包括IgA或IgA-TTG和IgG)可以识别患者有无肠道疾病。根据上述研究,近日研究者对抗体诊断程序的阳性和阴性预测值(PPV和NPV)进行考察。

研究招募了898名患儿接受十二指肠活检分析确认或排除乳糜泻并将结果与抗体诊断结果相比较。抗体测试结果将患者区分为无腹腔疾病类别(检测发现抗体浓度低于1倍ULN)或腹腔疾病(至少1法测定抗体浓度超过10倍ULN )。

研究参与者中,活检分析确认,有592名儿童有肠道疾病,345人无肠道疾病,24人无最终诊断结果。TTG-IgA测试的阳性预测率为0.988阴性预测率为0.934,TTG-DGL测试的阳性预测率为0.988阴性预测率为0.958。基于外推模型,研究者认为抗体诊断对于发病率低至4%的疾病其阳(阴)性预测率也可以超过0.95。肌内膜抗体和HLA配型不会造成假阳性结果。

研究认为,抗体检测是一种有效的儿科肠道疾病活检替代方法。

原文出处:


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    2017-05-04 许安
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createdTime=Sun Apr 30 14:21:21 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192099, encodeId=a97d192099f7, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sun Apr 30 09:24:09 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
  8. 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createdTime=Sun Apr 30 14:21:21 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192099, encodeId=a97d192099f7, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sun Apr 30 09:24:09 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-05-01 天涯183

    非常好的文章,学习了,很受益

    0

  9. 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createdTime=Sun Apr 30 14:21:21 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192099, encodeId=a97d192099f7, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sun Apr 30 09:24:09 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 天涯183

    非常好的文章,学习了,很受益

    0

  10. 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createdTime=Sun Apr 30 14:21:21 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192099, encodeId=a97d192099f7, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sun Apr 30 09:24:09 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 thlabcde

    好东西学习了!

    0

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