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Blood:异基因造血干细胞移植后非复发性死亡的预后标志物

2020-02-03 QQY MedSci原创

目前仍缺乏对儿科年龄组异基因造血干细胞移植(HCT)后非复发性死亡(NRM)的预后生物标志物的评估。为了满足这一需求,研究人员进行了一项前瞻性队列研究(NCT02194439)。招募了415位于2013年-2018年期间进行治疗的患者:170位不超过10岁的儿童和245位10岁以上的个体,包括儿童和成年人。在HCT前和HCT后第7天、14天和21天分别对4个血浆生物标志物(刺激因子-2[ST2]、

目前仍缺乏对儿科年龄组异基因造血干细胞移植(HCT)后非复发性死亡(NRM)的预后生物标志物的评估。为了满足这一需求,研究人员进行了一项前瞻性队列研究(NCT02194439)。

招募了415位于2013年-2018年期间进行治疗的患者:170位不超过10岁的儿童和245位10岁以上的个体,包括儿童和成年人。

在HCT前和HCT后第7天、14天和21天分别对4个血浆生物标志物(刺激因子-2[ST2]、白介素-6、再生胰岛驱动因子3α[REG3α]和肿瘤坏死因子受体1[TNFR1])进行评估。

研究人员对NRM进行了里程碑式的分析,将≤10岁的队列进一步一分为二,并使用每个生物标志物中位数作为高、低风险组的截止值。

HCT后生物标志物分析表明,在不超过10岁的患儿和10岁以上的患儿/成年患者中,ST2 (>26 ng/mL)、TNFR1 (>3441 pg/mL)和REG3α(>25 ng/mL)与NRM均相关。

将HCT前的生物标志物纳入分析时,在两个队列中,只有ST2仍具有显著性。经根据显著的协变量(种族、恶性疾病、移植物、GVHD预防)进行调整之后,ST2仅在≤10岁的受者中与NRM相关。

在HCT后前3周,ST2、TNFR1和REG3α试验对于儿童和成年患者的NRM均具有预测价值。HCT前的ST2是≤10岁儿童NRM的预后生物标志物,可促进进一步分层。

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  5. 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  6. 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href='/topic/show?id=3ef610019167' target=_blank style='color:#2F92EE;'>#预后标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100191, encryptionId=3ef610019167, topicName=预后标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b24e13440329, createdName=ms7514935887898259, createdTime=Wed Feb 05 02:48:00 CST 2020, time=2020-02-05, status=1, ipAttribution=)]
    2020-02-06 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

  7. 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  8. 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  9. 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    2020-02-05 俅侠
  10. 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中心点:抗CD117抗体可抑制并清除正常人HSCs。在MDS异种移植模型中,抗CD117抗体可清除人MDS细胞,促进正常人HSCs的移植。摘要:骨髓增生异常综合征(MDS)是一种克隆性疾病,可导致无效造血,并与转化成急性白血病的风险增加相关。MDS起源于造血干细胞(HSCs);因此,成功清除MDS HSCs是所有治疗方案的核心部分。但是,目前的治疗措施,包括异基因造血干细胞抑制(HCT),均不能消

2019 JSHCT临床实践建议:异基因造血干细胞移植后人类疱疹病毒6B脑炎的诊断和管理

2019年11月,日本造血干细胞移植学会(JSHCT)发布了异基因造血干细胞移植后人类疱疹病毒6B脑炎的诊断和管理建议,人类疱疹病毒(HHV)-6B在激活在异基因造血干细胞移植后比较常见,HHV-6B疾病可能因此而发展,其中HHV-6B是一种严重致命的并发症。本文主要针对异基因造血干细胞移植后人类疱疹病毒6B脑炎的诊断和管理提供指导建议。

Blood:B细胞在体外对IL-21的反应或可作为IL2RG/JAK3缺陷 SCID患者进行异基因造血干细胞移植后体液免疫的生物标志物

中心点:IL2RG/JAK3缺陷的B细胞在造血干细胞移植后仍保留固有的缺陷,即使滤泡辅助T细胞获得重构。B细胞在体外对IL-21的反应或可作为IL2RG/JAK3缺陷 SCID患者进行异基因造血干细胞移植后体液免疫的生物标志物。摘要:对于合并重度免疫缺陷(SCID)但无体液免疫异常的患者,予以异基因造血干细胞移植(HSCT),特别是源于无血缘的供体时,供体T细胞在患者体内的存活率和功能多变。SCI

2018 中国白血病异基因造血干细胞移植后复发的监测,治疗和预防共识(英文版)

同种异体造血肝细胞移植(allo-HSCT)是白血病患者一项重要的治疗方法,然而,疾病复发仍是移植后患者死亡的主要原因。本文主要总结了白血病异基因造血干细胞移植后复发的监测,治疗和预防的相关内容并提出相应指导建议。

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