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JACC:主动脉瓣狭窄女性怀孕有风险,受孕前需谨慎

2016-10-11 MedSci MedSci原创

在主动脉瓣狭窄(AS)女性中,目前关于母体风险和胎儿结果的报告结果都是有争议的。来自德国的研究人员开展了一项研究,作者试图在一个大型队列中调查AS患者的母体和胎儿结局。妊娠和心脏病登记注册表(ROPAC)是一个全球性,前瞻性的结构性心脏病女性观察性登记,该登记注册提供了一个独特的大型研究人群。研究人员分析了中度(峰值梯度36至63mm Hg)和严重AS(峰值梯度≥64mmHg)女性的数据。在ROP

在主动脉瓣狭窄(AS)女性中,目前关于母体风险和胎儿结果的报告结果都是有争议的。

来自德国的研究人员开展了一项研究,作者试图在一个大型队列中调查AS患者的母体和胎儿结局。

妊娠和心脏病登记注册表(ROPAC)是一个全球性,前瞻性的结构性心脏病女性观察性登记,该登记注册提供了一个独特的大型研究人群。研究人员分析了中度(峰值梯度36至63mm Hg)和严重AS(峰值梯度≥64mmHg)女性的数据。

在ROPAC队列的2,966名孕妇中,作者确定了96例至少有中度AS的女性(34例严重AS)。在怀孕期间和分娩后第一周没有观察到死亡。然而,20.8%的女性在怀孕期间因心脏原因住院治疗。与中度AS相比,严重AS女性因心脏原因住院的比例更高(35.3% vs 12.9%; p=0.02),在严重的,症状性AS患者中比例达到最高(42.1%)。6.7%的孕妇有无症状心衰,26.3%有症状性心衰,但可以通过治疗进行管理,只有1名症状性患者在妊娠之前接受球囊扩张术。严重AS女性的后代低出生体重比例显著较高(35.0% vs 6.0%; p=0.006)。

AS怀孕女性,包括那些严重AS女性,死亡率接近于零。然而,症状性和严重的AS女性患心衰的风险较高,尽管心衰几乎都能够通过治疗进行管理,但这也导致了较高的住院率。该研究结果强调了对受孕前患者进行咨询和评估的重要性。

原始出处:

Stefan Orwat,Gerhard-Paul Diller,Iris M. van Hagen,et al.Risk of Pregnancy in Moderate and Severe Aortic Stenosis,JACC,2016.10.11


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    2017-01-18 szhvet
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    2016-11-06 hbwxf
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    2017-01-30 楚秀娟
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1659563, encodeId=2604165956327, content=<a href='/topic/show?id=c42845239ef' target=_blank style='color:#2F92EE;'>#孕前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45239, encryptionId=c42845239ef, topicName=孕前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c8925003801, createdName=szhvet, createdTime=Wed Jan 18 12:15:00 CST 2017, time=2017-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853586, encodeId=7cc218535860a, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 06 16:15:00 CST 2016, time=2016-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677780, encodeId=9b6416e7780d4, content=<a href='/topic/show?id=02723804379' target=_blank style='color:#2F92EE;'>#受孕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38043, encryptionId=02723804379, topicName=受孕)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=795f27597722, createdName=楚秀娟, createdTime=Mon Jan 30 19:15:00 CST 2017, time=2017-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325306, encodeId=6cc713253065b, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332407, encodeId=a89e133240ec6, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415084, encodeId=7942141508408, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145140, encodeId=7b45145140d3, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 19:54:33 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145139, encodeId=589514513917, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 19:54:26 CST 2016, time=2016-10-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1659563, encodeId=2604165956327, content=<a href='/topic/show?id=c42845239ef' target=_blank style='color:#2F92EE;'>#孕前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45239, encryptionId=c42845239ef, topicName=孕前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c8925003801, createdName=szhvet, createdTime=Wed Jan 18 12:15:00 CST 2017, time=2017-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853586, encodeId=7cc218535860a, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 06 16:15:00 CST 2016, time=2016-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677780, encodeId=9b6416e7780d4, content=<a href='/topic/show?id=02723804379' target=_blank style='color:#2F92EE;'>#受孕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38043, encryptionId=02723804379, topicName=受孕)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=795f27597722, createdName=楚秀娟, createdTime=Mon Jan 30 19:15:00 CST 2017, time=2017-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325306, encodeId=6cc713253065b, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332407, encodeId=a89e133240ec6, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415084, encodeId=7942141508408, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145140, encodeId=7b45145140d3, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 19:54:33 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145139, encodeId=589514513917, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 19:54:26 CST 2016, time=2016-10-11, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1659563, encodeId=2604165956327, content=<a href='/topic/show?id=c42845239ef' target=_blank style='color:#2F92EE;'>#孕前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45239, encryptionId=c42845239ef, topicName=孕前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c8925003801, createdName=szhvet, createdTime=Wed Jan 18 12:15:00 CST 2017, time=2017-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853586, encodeId=7cc218535860a, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 06 16:15:00 CST 2016, time=2016-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677780, encodeId=9b6416e7780d4, content=<a href='/topic/show?id=02723804379' target=_blank style='color:#2F92EE;'>#受孕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38043, encryptionId=02723804379, topicName=受孕)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=795f27597722, createdName=楚秀娟, createdTime=Mon Jan 30 19:15:00 CST 2017, time=2017-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325306, encodeId=6cc713253065b, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332407, encodeId=a89e133240ec6, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415084, encodeId=7942141508408, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145140, encodeId=7b45145140d3, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 19:54:33 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145139, encodeId=589514513917, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 19:54:26 CST 2016, time=2016-10-11, status=1, ipAttribution=)]
    2016-10-11 知难而进

    继续关注!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1659563, encodeId=2604165956327, content=<a href='/topic/show?id=c42845239ef' target=_blank style='color:#2F92EE;'>#孕前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45239, encryptionId=c42845239ef, topicName=孕前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c8925003801, createdName=szhvet, createdTime=Wed Jan 18 12:15:00 CST 2017, time=2017-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853586, encodeId=7cc218535860a, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 06 16:15:00 CST 2016, time=2016-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677780, encodeId=9b6416e7780d4, content=<a href='/topic/show?id=02723804379' target=_blank style='color:#2F92EE;'>#受孕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38043, encryptionId=02723804379, topicName=受孕)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=795f27597722, createdName=楚秀娟, createdTime=Mon Jan 30 19:15:00 CST 2017, time=2017-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325306, encodeId=6cc713253065b, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332407, encodeId=a89e133240ec6, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415084, encodeId=7942141508408, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Oct 13 00:15:00 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145140, encodeId=7b45145140d3, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 19:54:33 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145139, encodeId=589514513917, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 19:54:26 CST 2016, time=2016-10-11, status=1, ipAttribution=)]
    2016-10-11 知难而进

    谢谢分享!

    0

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Am J Cardiol: 经导管主动脉瓣置换的死亡率没有性别差异

近年来由于经导管主动脉瓣置换(TAVR)的研究进展,重度主动脉瓣狭窄的治疗有了显著的改变。最近的CoreValve瓣膜研究表明,手术风险较高的患者,瓣膜主动脉瓣置换效果较好。但这种治疗的患者特征和预后的性别差异的研究较少。研究者比较应用CoreValve瓣膜行TAVR男性和女性的基线特征及临床预后。总共纳入3687例患者(1708名女性和1979名男性)。在基线水平,女性年纪稍大,比较脆弱,但她们

Circulation:高风险和不能手术的主动脉瓣狭窄患者TAVR的长期效果

在高风险(HR)和不能手术患者的经导管主动脉瓣置换术的初始PARTNER试验中,1年时死亡率在HR患者中是24%,不能手术患者中是31%。SAPIEN3导管主动脉瓣置换系统的最近30天的成果报告显示不良事件的发生率很低,但鲜为人知的是此装置的长期结果。在2013年10月和2014年9月间,583例HR(65%)或不能手术(35%)的患者通过经股动脉(84%)或心尖/主动脉16%)手术在美国29个地

Heart:无症状性主动脉瓣狭窄患者体内Galectin-3的价值和影响因素

目的对于患有无症状严重主动脉瓣狭窄(AS)的患者而言,是否出现心肌纤维化可作为一个影响患者是否手术的预测因子。使用核磁共振检测可得出结论,但近年来较少使用,且使用生物标记物替代并十分可取。 研究人员分析了galectin-3(与心肌纤维化有关的生物标志物)的决定因素和预后价值。 方式2006-2013年参与两项正在进行的研究(COFRASA/GENERAC)且至少患有轻度AS的患者参与研究,旨在评

JACC:对无症状严重主动脉瓣狭窄患者,换瓣术优于保守治疗

对于无症状的严重的主动脉瓣狭窄 (AS)患者,目前的指南建议,观察随访直到症状出现才行主动脉瓣置换术 (AVR) 。研究者对无症状的严重AS患者进行了一项研究,探究一经诊断就行AVR治疗和保守策略两种方案对患者的长期影响。该研究在2003年1月-2011年12月间,从多中心注册库纳入了3815名严重AS患者(主峰喷射速度>4.0 m/s,或平均主动脉压力梯度>40 mmHg,或主动脉瓣

JACC:重度主动脉瓣狭窄患者的介入治疗与主动脉瓣置换术

    背景  经导管主动脉瓣置换术(TAVR)是在一定的高风险手术的严重主动脉瓣狭窄患者的一个选择。但并不知道是否可以将TAVR安全地引入到低风险患者。    意义  在NOTION(北欧主动脉瓣膜干预试验)随机临床试验中,比较所有研究队列的患者接受主动脉瓣置换手术(SAVR)和TAVR的区别。    方法 &nbs

JACC:主动脉瓣置换术可降低保守LEVF和低梯度的主动脉瓣狭窄患者的死亡率

低平均跨瓣压力梯度(<40mm Hg)和主动脉瓣面积小(<1.0cm2)的患者并患有主动脉瓣狭窄(AS)和保守左室射血分数引起了人们对主动脉瓣置换术(AVR)的狭窄和生存利益的实际严重程度的不确定性。这项研究分析了AVR对低梯度(LG)AS和保守左室射血分数患者死亡率和存活率的影响,包括反常的低流量(即每搏输出量指数<35ml/m2),低梯度(LF-LG)和正常流量,低梯度(NF

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