Baidu
map

Circulation发布研究:LDL-C维持在新生儿水平(50 mg/dL),可降约1/3的心梗和卒中风险

2016-12-19 卢芳 中国循环杂志

对于有高胆固醇血症的患者而言,国内外指南均建议将低密度脂蛋白胆固醇(LDL-C)降低在100 mg/dL以下,那么如果把LDL-C降低在新生儿水平合适吗? 近期一项发表在Circulation上的研究显示,对于这些患者将LDL-C降低在新生儿水平,也就是低于50 mg/dL,是安全的,而且可降低约1/3的心梗、卒中或致死性心脏病风险。 研究还显示,每降低39 mg/dL的 LDL-C,

对于有高胆固醇血症的患者而言,国内外指南均建议将低密度脂蛋白胆固醇(LDL-C)降低在100 mg/dL以下,那么如果把LDL-C降低在新生儿水平合适吗?

近期一项发表在Circulation上的研究显示,对于这些患者将LDL-C降低在新生儿水平,也就是低于50 mg/dL,是安全的,而且可降低约1/3的心梗、卒中或致死性心脏病风险。

研究还显示,每降低39 mg/dL的 LDL-C,心梗、卒中、心绞痛以及心血管死亡风险降低24%。

这项研究共纳入10项研究中5000例平均年龄为60岁的受试者。绝大数患者均罹患心血管病,且之前均被诊断为高胆固醇血症,平均LDL-C水平为125 mg/dL。其中一部分患者接受他汀治疗,还有超出半数患者接受他汀和阿利库单抗(alirocumab,每隔两周注射一次)的联合治疗。随访时间为3个月~2年不等。

研究者表示,该研究还有待更长期的随访数据。


原始出处:

Kate Wighton. Lowering cholesterol to 'levels of a new-born' cuts heart attack risk. Medicalxpress. December 16, 2016.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1281229, encodeId=ab641281229bb, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422543, encodeId=4f9b14225434f, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164344, encodeId=ad231643441f, content=谢谢分享研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG5854E0519E0D81311.jpg, createdBy=3ff51679470, createdName=1039415152, createdTime=Tue Dec 20 11:02:20 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164085, encodeId=62d31640858f, content=学习了好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 19 13:52:59 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164080, encodeId=b84b164080d2, content=厉害啊!!我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Dec 19 13:34:26 CST 2016, time=2016-12-19, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1281229, encodeId=ab641281229bb, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422543, encodeId=4f9b14225434f, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164344, encodeId=ad231643441f, content=谢谢分享研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG5854E0519E0D81311.jpg, createdBy=3ff51679470, createdName=1039415152, createdTime=Tue Dec 20 11:02:20 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164085, encodeId=62d31640858f, content=学习了好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 19 13:52:59 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164080, encodeId=b84b164080d2, content=厉害啊!!我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Dec 19 13:34:26 CST 2016, time=2016-12-19, status=1, ipAttribution=)]
    2016-12-21 zhwj
  3. [GetPortalCommentsPageByObjectIdResponse(id=1281229, encodeId=ab641281229bb, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422543, encodeId=4f9b14225434f, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164344, encodeId=ad231643441f, content=谢谢分享研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG5854E0519E0D81311.jpg, createdBy=3ff51679470, createdName=1039415152, createdTime=Tue Dec 20 11:02:20 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164085, encodeId=62d31640858f, content=学习了好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 19 13:52:59 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164080, encodeId=b84b164080d2, content=厉害啊!!我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Dec 19 13:34:26 CST 2016, time=2016-12-19, status=1, ipAttribution=)]
    2016-12-20 1039415152

    谢谢分享研究成果

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1281229, encodeId=ab641281229bb, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422543, encodeId=4f9b14225434f, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164344, encodeId=ad231643441f, content=谢谢分享研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG5854E0519E0D81311.jpg, createdBy=3ff51679470, createdName=1039415152, createdTime=Tue Dec 20 11:02:20 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164085, encodeId=62d31640858f, content=学习了好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 19 13:52:59 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164080, encodeId=b84b164080d2, content=厉害啊!!我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Dec 19 13:34:26 CST 2016, time=2016-12-19, status=1, ipAttribution=)]
    2016-12-19 thlabcde

    学习了好东西

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1281229, encodeId=ab641281229bb, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422543, encodeId=4f9b14225434f, content=<a href='/topic/show?id=58b810e5814' target=_blank style='color:#2F92EE;'>#LDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10758, encryptionId=58b810e5814, topicName=LDL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382c3719677, createdName=zhwj, createdTime=Wed Dec 21 04:24:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164344, encodeId=ad231643441f, content=谢谢分享研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG5854E0519E0D81311.jpg, createdBy=3ff51679470, createdName=1039415152, createdTime=Tue Dec 20 11:02:20 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164085, encodeId=62d31640858f, content=学习了好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 19 13:52:59 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164080, encodeId=b84b164080d2, content=厉害啊!!我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Dec 19 13:34:26 CST 2016, time=2016-12-19, status=1, ipAttribution=)]
    2016-12-19 乐奕11

    厉害啊!!我的哥

    0

相关资讯

新生儿坏死性小肠结肠炎外科手术治疗专家共识

中华医学会小儿外科学分会新生儿外科学组系统分析国内外文献报道,结合我国现状及专家经验,对新生儿坏死性小肠结肠炎(NEC)外科手术时机、手术方法,肠造瘘手术方式及术后并发症的处理等达成共识,供同仁参考。

我看过理想的新生儿颅内出血图文解析!

新生儿颅内出血( neonatal intracranial hemorrhage,NICH)是新生儿期常见疾病,病死率高,为新生儿死亡和幸存儿神经系统发育障碍、智能落后的主要原因,常留下神经系统后遗症,对新生儿的健康成长非常不利,对该病的诊治是新生儿科的常规工作。NICH主要发病因素为产伤及缺氧,前者正逐渐减少,后者有增加趋势,其中在<32孕周、出生体重<1500g的未成熟儿高达

JAMA Pediatr:新生儿术前贫血可显著增加其术后死亡率

据发表于JAMA Pediatric的一项新的研究显示,新生儿心脏手术前贫血与其术后死亡率的增加相关。术前贫血是导致成人术后死亡的一个强有力的独立危险因素,但是在新生儿中是否也由此关系则尚未可知。研究采用回顾性分析设计,使用来自美国外科学会国家外科质量改进计划的2012年和2013年的儿童数据库的数据。记录所有新生儿(0-30天)术前红细胞压积值。贫血定义为血细胞比容小于40%。结果纳入了2764

Neurology:新生儿维生素D缺乏与多发性硬化症的风险增加有关

新生儿时低浓度的维生素D与患多发性硬化症的风险增加有关,在孕妇维生素D不足高患病率的情况下,本研究的观察结果可能对公共健康具有重要意义。

Clin Nutr:脐血维生素D缺乏和不足的危险因素有哪些?

维生素D缺乏定义为血清25羟维生素D(s-25(OH)D) <50 nmol/L,与低出生体重(BW)和胎盘重量(PW)以及胎盘发育的减少有关。我们的目的是评估和脐血维生素D缺乏(s-25(OH)D <25 nmol/L)和不足(s-25(OH)D 25–50 nmol/L)的患病率和危险因素,评估脐血s-25(OH)D水平与新生儿结局(BW、PW、PW/BW)之间的联系。研究对象来自

BMJ:你见过这样的脐部病变吗?——案例报道

患者男,8周大小,因持续性渗出的红色脐部病变就诊。他出生于正常的阴道分娩,在怀孕或出生时没有任何并发症。这个孩子没有医学史。用奶瓶喂养,体重符合预期。查体,脐部观察到浆液性红色病变。没有周围蜂窝织炎或感染的临床证据。三个问题:1.你觉得最有可能的诊断是什么?2.要考虑的鉴别诊断有哪些?3.如何管理这名患者?思考下,再看答案。1.最有可能的诊断:脐肉芽肿。2.鉴别诊断包括:先天性胃肠道和泌尿道的异常

Baidu
map
Baidu
map
Baidu
map