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Diabetes Care:艾塞那肽疗效安全性优于甘精胰岛素(IG)

2012-03-03 MedSci MedSci原创

  欧美学者的一项研究表明,接受每周一次艾塞那肽(EQW)治疗的患者在远期转归和安全性方面均优于甘精胰岛素(IG)治疗者。论文于2012年2月22日在线发表于《糖尿病治疗》(Diabetes Care)杂志。    研究者近期实施的一项研究表明,在单独服用二甲双胍或联用磺酰脲的2型糖尿病患者中,与每日应用IG相比,为期26周的EQW治疗在降低HbA1C、减少低血糖发生和进行性降低体重方

  欧美学者的一项研究表明,接受每周一次艾塞那肽(EQW)治疗的患者在远期转归和安全性方面均优于甘精胰岛素(IG)治疗者。论文于2012年2月22日在线发表于《糖尿病治疗》(Diabetes Care)杂志。

   研究者近期实施的一项研究表明,在单独服用二甲双胍或联用磺酰脲的2型糖尿病患者中,与每日应用IG相比,为期26周的EQW治疗在降低HbA1C、减少低血糖发生和进行性降低体重方面表现更为优异。此项84周扩展试验对EQW和IG的远期安全性和有效性进行了对比评估,评估内容包括HbA1C变化、实现HbA1C<7.0%和≤6.5%的患者比例、体重、低血糖发生率和总体安全性。

  结果显示,415例患者完成了26周试验,其中390例(EQW 194例,IG 196例)进入了扩展试验。在84周时,EQW和IG组的HbA1C基线降低分别为-1.2%和-1.0%(P=0.029);实现HbA1C7.0和≤6.5%的患者比例分别为44.6%和36.8%(P=0.084)以及31.3%和20.2%(P=0.009)。EQW患者体重降低2.1 Kg,IG组患者则增加2.4 Kg。

  在联用二甲双胍和磺酰脲的患者中,EQW和IG组的轻微低血糖发生率分别为24%和54%;在单用二甲双胍的患者相应比率分别为8%和32%。在发生率大于5%的不良事件中,腹泻和恶心在EQW组更为常见。

  链接:

  Safety and Efficacy of Once-Weekly Exenatide Compared With Insulin Glargine Titrated to Target in Patients With Type 2 Diabetes Over 84 Weeks

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    2012-07-27 baoya
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