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Scientific Reports: 术中低钠血症是肝移植术后一年死亡率的独立预测因子

2019-01-20 MedSci MedSci原创

我们已知术前低钠血症与肝移植(LT)死亡风险增加有关。在本项研究中研究人员试图调查术前和术中血清钠水平对LT后一年死亡率的影响

背景:
我们已知术前低钠血症与肝移植(LT)死亡风险增加有关。在本项研究中研究人员试图调查术前和术中血清钠水平对LT后一年死亡率的影响。

方法:
研究人员共纳入了1164例术前和术中可获得血清钠水平的患者。对一年死亡率进行了多变量调整的Cox回归分析。对术前和术中血清钠组进行倾向评分匹配分析,比较一年生存率。对于术前和术中钠,钠水平的最小p值截止值为130 mEq / L. 在多变量Cox回归分析中,术中低钠血症是一年死亡率的独立预测因子,而术前低钠血症则不是。Kaplan-Meier曲线显示,术前和术中血清钠组的一年死亡率存在显着差异。然而,在倾向评分匹配后,术前钠组的一年死亡率没有差异,而术中钠组之间存在显着差异。由平均钠<130 mEq / L定义的术中低钠血症与显着高的一年死亡率独立相关。

结论:
术中血清钠水平可能是比术前血清钠水平更好的预后预测因子。

原始出处:

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    2019-09-05 cy0324
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    2019-01-22 jichang
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    2019-01-22 zz12341238
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