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Lancet Infect Dis:疫苗对布基纳法索脑膜炎球菌携带及长期免疫的影响

2020-07-13 MedSci原创 MedSci原创

MenAfriVac疫苗对A群脑膜炎球菌携带者保护作用持续至少7年

近日研究人员评估了布基纳法索1-29岁人群接受A 群脑膜炎球菌血清型结合疫苗(MenAfriVac)接种后,疫苗对脑膜炎球菌携带和免疫的长期影响。

2016年5月2日至2017年11月6日,研究人员在布基纳法索的两个地区对9个月至36岁人群进行了四项脑膜炎球菌携带的横断面研究。收集人口学资料和口咽拭子数据,使用全基因组测序对脑膜炎球菌分离株进行了特征分析。

13758名参与者,其中1035人是脑膜炎球菌携带者,估计脑膜炎球菌携带率为7.60%,其中血清W型占0.48%,血清C型占0.10%,血清E型占0.03%,无血清A型病例,不可分型占6.98%。按地区划分,患病率从5.44%-9.14%不等,年龄患病率从3.39%到10.43%。经克隆复合体分析,934株非群体分离物中822株(88%)为CC192型,所有83株(100%)血清群 w 分离物均为CC11型,13株血清群 c 型分离物中9株(69%)为CC10217型。

研究认为,MenAfriVac疫苗对A群脑膜炎球菌携带者保护作用持续至少7年。

原始出处:

Sarah Mbaeyi et al. Meningococcal carriage 7 years after introduction of a serogroup A meningococcal conjugate vaccine in Burkina Faso: results from four cross-sectional carriage surveys.Lancet Infect Dis. July 09,2020.

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    2020-09-15 howi
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    2020-08-27 14818eb4m67暂无昵称

    学习了

    0

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    2020-07-13 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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