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Clinical Translational Gastroenterology: 接受双重抗血小板药物治疗的患者行冷圈套息肉切除术后并发症风险

2019-12-11 不详 MedSci原创

冷圈套息肉切除术(CSP)是一种用于切除≤10 mm的息肉的安全有效的方法。本项研究的目的是比较接受双重抗血小板治疗(DAPT)的患者在停用和继续使用噻吩并吡啶类药物后行CSP后发生重大出血和血栓栓塞事件的风险。

背景及目的:
冷圈套息肉切除术(CSP)是一种用于切除≤10 mm的息肉的安全有效的方法。本项研究的目的是比较接受双重抗血小板治疗(DAPT)的患者在停用和继续使用噻吩并吡啶类药物后行CSP后发生重大出血和血栓栓塞事件的风险。

方法:
该研究是一项单中心,非劣效,随机对照研究,研究对象为2015年10月至2016年10月接受结肠镜检查的患者。接受DAPT≤10 mm息肉的患者被随机分为DAPT组(患者继续接受DAPT)或阿司匹林组(患者停用噻吩并吡啶类药物1周)。主要结果是临床上明显的出血。次要结果包括术中出血。

结果:
总共有42例息肉104例患者被分配到DAPT组,45例息肉101例患者被分配到阿司匹林组。两组患者的人口统计学特征(包括息肉的大小,位置,形状和病理)相似。两组的术中出血和无明显出血的发生率也相似(4.8%vs 2.2%,P=0.608;19.0%vs 8.9%,P=0.170)。两组均未发生血栓栓塞事件。DAPT组中只有1名患者(2.4%)表现出临床上明显的出血。阿司匹林组未见明显出血。

讨论:
持续接受DAPT的患者行CSP对息肉≤10mm进行切除,其临床显着出血率为2.4%。因此,即使患者在行DAPT治疗,CSP是患者去除小息肉一种安全的方法。

原始出处:
Won, Dae Ma. Et al. Cold Snare Polypectomy in Patients Taking Dual Antiplatelet Therapy. Clinical Translational Gastroenterology.2019.

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    2020-03-05 丁鹏鹏
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    2020-08-12 bsmagic9140
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  4. 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  5. 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  6. 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  7. 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createdBy=e2dd327, createdName=许安, createdTime=Thu Nov 05 02:03:00 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067479, encodeId=ed31206e4790a, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sun Apr 26 07:03:00 CST 2020, time=2020-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064915, encodeId=af542064915ae, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Sep 08 23:03:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776709, encodeId=6f4a1e76709a2, content=<a href='/topic/show?id=fbf78905420' target=_blank style='color:#2F92EE;'>#血小板药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89054, encryptionId=fbf78905420, topicName=血小板药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ff838995252, createdName=songbq, createdTime=Mon Jun 01 00:03:00 CST 2020, time=2020-06-01, status=1, ipAttribution=)]
    2020-11-05 许安
  8. 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  9. 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  10. 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createdBy=e2dd327, createdName=许安, createdTime=Thu Nov 05 02:03:00 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067479, encodeId=ed31206e4790a, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sun Apr 26 07:03:00 CST 2020, time=2020-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064915, encodeId=af542064915ae, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Sep 08 23:03:00 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776709, encodeId=6f4a1e76709a2, content=<a href='/topic/show?id=fbf78905420' target=_blank style='color:#2F92EE;'>#血小板药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89054, encryptionId=fbf78905420, topicName=血小板药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ff838995252, createdName=songbq, createdTime=Mon Jun 01 00:03:00 CST 2020, time=2020-06-01, status=1, ipAttribution=)]
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