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Circulation:妊娠期高血压与随后罹患各类心血管疾病风险的相关性

2019-09-26 MedSci MedSci原创

妊娠高血压和常见心血管疾病之间是否具有相关性?目前尚无大规模的研究。现研究人员对子痫前期、妊娠期高血压和随后发生的12种不同心血管疾病之间的关系进行研究。研究人员采用1997年-2016年的电子健康记录,对英国130万女性进行研究,平均分娩年龄为28岁,共190万次分娩记录。在20年研究期间,共观察到18624例心血管事件,其中65%发生于年龄不足40岁的女性。与无妊娠期高血压的女性相比,一次或多

妊娠高血压和常见心血管疾病之间是否具有相关性?目前尚无大规模的研究。现研究人员对子痫前期、妊娠期高血压和随后发生的12种不同心血管疾病之间的关系进行研究。

研究人员采用1997年-2016年的电子健康记录,对英国130万女性进行研究,平均分娩年龄为28岁,共190万次分娩记录。

在20年研究期间,共观察到18624例心血管事件,其中65%发生于年龄不足40岁的女性。与无妊娠期高血压的女性相比,一次或多次妊娠时发生子痫前期的女性发生中风、脏动脉粥样硬化事件、外周动脉疾病、心衰房颤心血管死亡、慢性高血压的风险比分别为1.9(95% CI 1.53-2.35)、1.67 (1.54–1.81)、1.82 (1.34–2.46)、2.13 (1.64–2.76)、1.73 (1.38–2.16)、2.12 (1.49–2.99)和4.47 (4.32–4.62)。根据子痫前期的状态不同,妊娠一年后各心血管疾病的累计发生率也明显不同。妊娠期高血压疾病也观察到类似的相关性,而先兆子痫患者后期各类心血管疾病的患病风险略微更高一些。

妊娠期高血压疾病,包括子痫前期,对于12种心血管疾病和慢性高血压都有类似的风险增加效应,而且其影响在妊娠后不久就很明显。妊娠期高血压病应被作为心血管事件的自然筛查指标。

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