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Am Heart J:疑似CAD患者——CAC评分和SPECT心肌灌注显像后心血管药物的改变

2017-06-12 吴刚 环球医学

具有正常的心肌灌注显像(MPI)结果的有症状患者中,冠状动脉钙化(CAC)评分对随后心血管药物使用改变的影响还未确定。2017年4月,发表在《Am Heart J》的一项研究评估了疑似冠状动脉疾病的患者中,CAC评分和正常单光子发射计算机断层显像(SPECT)MPI后,阿司匹林和他汀使用的改变。


具有正常的心肌灌注显像(MPI)结果的有症状患者中,冠状动脉钙化(CAC)评分对随后心血管药物使用改变的影响还未确定。2017年4月,发表在《Am Heart J》的一项研究评估了疑似冠状动脉疾病的患者中,CAC评分和正常单光子发射计算机断层显像(SPECT)MPI后,阿司匹林和他汀使用的改变。

本研究中,1033名稳定的有症状患者入组,这些患者无已知的冠状动脉疾病史,具有正常的SPECT MPI,同时进行CAC评分。所有患者都有影像学的临床指征,主要是非典型胸痛和呼吸困难,并从医院的门诊中转诊过来。试验后药物改变的数据(随后门诊就诊时开始或停用阿司匹林和他汀治疗)都进行了回顾性收集。患者基于他们的CAC评分分为4组。

结果显示,患者平均61±11岁,39%为男性。基线时,35%的患者使用阿司匹林,39%使用他汀。CAC评分为0、1~99、100~399和≥400的患者中,分别有1%、4%、9%和9%的患者开始阿司匹林,0%、7%、18%和24%的患者开始他汀(P<0.001)。相应CAC评分组中,19%、11%、7%和1%的患者停用阿司匹林,8%、6%、2%和0%的患者停用他汀(P<0.001)。校正了风险因素和基线药物使用的差异后,CAC评分的增加与试验后阿司匹林(CAC评分为1~99、100~399和≥400的比值比分别为4.6、11.2和27.1;P<0.001)和他汀使用(CAC评分为1~99、100~399和≥400的比值比分别为4.4、19.4和60.9;P<0.001)独立相关。

结果表明,正常SPECT MPI患者中,较高的CAC评分与阿司匹林和他汀初始治疗相关。CAC评分较低的患者中,更可能停用心脏保护药物。CAC评分与试验后他汀和阿司匹林的使用独立相关

原始出处:

Engbers EM, Timmer JR, Mouden M, et al. Changes in cardiovascular medication after coronary artery calcium scanning and normal single photon emission computed tomography myocardial perfusion imaging in symptomatic patients. Am Heart J. 2017 Apr;186:56-62. doi: 10.1016/j.ahj.2017.01.009. Epub 2017 Jan 19.

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    2018-04-07 feather89
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    2017-06-14 zhaojie88
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    2017-06-14 slcumt

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