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Clin Gastroenterology H: 酒精性肝炎患者出院30天之内的酒精戒断与再入院,复发和死亡减少相关

2020-01-22 不详 MedSci原创

因酒精性肝炎(AH)入院的患者再次入院和死亡的风险均会增加。本项研究旨在确定酒精性肝炎患者与再入院,酒精复发和死亡率相关的因素。

背景与目标
因酒精性肝炎(AH)入院的患者再次入院和死亡的风险均会增加。本项研究旨在确定酒精性肝炎患者与再入院,酒精复发和死亡率相关的因素。

方法
研究人员对1999年至2016年间的AH患者进行了回顾性分析(试验队列,n=135)。同时,研究人员在2013年至2017年的多中心AH研究联盟中对患者进行了前瞻性分析,验证了我们的发现(验证队列,n= 159)。酒精再染定义为出院后30天内的任何酒精消耗。早期戒酒的定义是出院后30天内住院或门诊参加成瘾治疗或互助小组。

结果
两个队列的30天再入院率均为30%。在试验队列中,酒精复发率是37%,在验证队列中是34%。出院后,试验队列的27例患者(20%)和验证队列的19例患者(16%)进行了早期酒精戒断。中位随访时间为2.8年,有53例死亡(39%),中位随访时间为1.3年,有42例死亡(26%)。在试验队列中,早期酒精戒断降低了30天再入院的机率(调整后的优势比[AOR] 0.16; 95%CI,0.04-0.65;P= .01),30天酒精再染(AOR,0.11; 95% CI,0.02-0.53;P<.001)和死亡风险(经调整的危险比[AHR],0.20; 95%CI,0.05-0.56;P= .001)。在验证队列中,早期酒精戒断降低了30天再入院的机率(AOR,0.30; 95%CI,0.09–0.98;P = .04),30天酒精复发(AOR 0.09; 95%CI,0.01–0.73;P = .02)和死亡(AHR,0.20; 95%CI,0.01-0.94;P = .04)。结合酒精康复和胆红素的模型确定了30天内再次入院的患者,接受者操作特征曲线下的面积为0.73。

结论
本项研究发现早期戒酒可以降低医院再次住院,饮酒复发和死亡的风险。

原始出处:

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    2020-05-12 许安
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