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Diabetic Med:葡萄糖耐量异常和Ⅱ型糖尿病患者的行走方式改变和不稳定性增加与小纤维神经病变有关?

2017-06-28 MedSci MedSci原创

近日,国际杂志 《Diabetic medicine》上在线发表一项关于调查葡萄糖耐量异常患者和Ⅱ型糖尿病患者的行走方式和动态摇摆(不稳定)的变化与神经病变和维生素D水平的严重程度的相关性研究。

近日,国际杂志 《Diabetic medicine》上在线发表一项关于调查葡萄糖耐量异常患者和Ⅱ型糖尿病患者的行走方式和动态摇摆(不稳定)的变化与神经病变和维生素D水平的严重程度的相关性研究。

共有20名Ⅱ型糖尿病患者,20名葡萄糖耐量异常患者和20名无Ⅱ型糖尿病或葡萄糖耐量异常患者(对照组)使用运动分析系统和力平台进行步态分析,并详细评估神经病变和血清25羟基维生素D水平。

与对照组相比,Ⅱ型糖尿病患者的葡萄糖耐量异常参与者的踝关节强度(P = 0.01)和力度(P = 0.003)行走速度(P = 0.008)是稳定的,在Ⅱ型糖尿病患者这些数据却明显更低。然而与对照组相比,葡萄糖耐量异常参与者的步宽(P = 0.005)和动态中 - 外侧摇摆(P = 0.007)显著较高,后期最大运动(P = 0.000)较低,但在Ⅱ型糖尿病患者是稳定的。角膜神经纤维长度(P = 0.001)和角膜神经分支密度(P = 0.001)与动态内侧摆动相关,但振动感知阈值不相关( P = 0.19)。血清25羟基维生素D水平在各组间差异无统计学意义(P = 0.10),与动态摇摆的任何步态变量或测量结果无关。

葡萄糖耐量降低的参与者,行走方式和动态摇摆的早期异常明显,而Ⅱ型糖尿病患者的踝关节强度,力量和步行速度有所降低。不稳定性与小纤维相关,但与大纤维神经病变无关,维生素D水平与行走变量之间没有显著关系。

原始出处:

M. M. Almurdhi, S. J. Brown, F. L. Bowling, et al. Altered walking strategy and increased unsteadiness in participants with impaired glucose tolerance and Type 2 diabetes relates to small-fibre neuropathy but not vitamin D deficiency.

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    2019-02-26 1252624dm26暂无昵称

    神经病,做些有用的要死啊

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  5. 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  6. 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topicList=[TopicDto(id=76853, encryptionId=0930e68532d, topicName=糖耐量异常)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Thu Sep 14 07:26:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474229, encodeId=af0614e4229f5, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 30 11:26:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491269, encodeId=e2c1149126973, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, 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  7. 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  8. 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encodeId=c3fa1500569c2, content=<a href='/topic/show?id=b2cbe6849b2' target=_blank style='color:#2F92EE;'>#糖耐量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76849, encryptionId=b2cbe6849b2, topicName=糖耐量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e659435909, createdName=fengxx, createdTime=Fri Jun 30 11:26:00 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-06-30 axin012
  9. 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  10. 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    2017-06-30 fengxx

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