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Nat Med：蛋白质Sema4D遏制骨骼形成(附点评)

2011-11-05 MedSci原创 MedSci原创

Sema4D骨骼
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MedSci点评:这是刚刚发现的新的骨形成相关信号Sema4D/Plexin-B1,与以往骨形成相关信号,如UPP-SMADs, Eph/ephrin,BMP6-SMADs,OPG/RANKL/RANK系统,Wnt/β2-catenin,DKK/LRP5/6信号等,这一新的信号发现,将有助于人们对骨质疏松,骨吸收以及骨形成的理解,同样,也会产生大量相关文章。希望看到本文的作者，可以依此信号，或将这

MedSci点评:这是刚刚发现的新的骨形成相关信号Sema4D/Plexin-B1,与以往骨形成相关信号,如UPP-SMADs, Eph/ephrin,BMP6-SMADs,OPG/RANKL/RANK系统,Wnt/β2-catenin,DKK/LRP5/6信号等,这一新的信号发现,将有助于人们对骨质疏松,骨吸收以及骨形成的理解,同样,也会产生大量相关文章。希望看到本文的作者，可以依此信号，或将这一新发现的信号与以往研究的信号相互作用进行研究，很容易发现一些新的有价值的线索。当然，还可以从临床病例入手进行研究。如果需要相关协助，可以与MedSci联系。 日本研究人员日前发现一种遏制骨骼形成的蛋白质，通过抑制这种蛋白质的功能，研究人员成功地在实验鼠身上实现了骨骼再生。 东京医科齿科大学研究人员报告说，他们在实验中发现，分解骨质的破骨细胞会大量分泌一种与调节免疫机能有关的蛋白质“Sema4D”，这种蛋白质会遏制成骨细胞的产生，进而阻止新骨骼的形成。 研究人员制作出能够与“Sema4D”蛋白质结合从而遏制其发挥作用的抗体，然后注射到患有骨质疏松症的实验鼠体内，结果发现其骨骼成功再生，骨密度也

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    2012-03-02 柳叶一刀

    #白质#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1765464, encodeId=e22c1e65464be, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Mar 02 08:42:00 CST 2012, time=2012-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879095, encodeId=ef8b18e9095b8, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Dec 25 22:42:00 CST 2011, time=2011-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296842, encodeId=87b2129684255, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317175, encodeId=8dc0131e17551, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605621, encodeId=bce2160562189, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=)]
    2011-12-25 liye789132251

    #Nat#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1765464, encodeId=e22c1e65464be, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Mar 02 08:42:00 CST 2012, time=2012-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879095, encodeId=ef8b18e9095b8, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Dec 25 22:42:00 CST 2011, time=2011-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296842, encodeId=87b2129684255, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317175, encodeId=8dc0131e17551, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605621, encodeId=bce2160562189, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=)]
    2011-11-07 cmj8wellington

    #蛋白质#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1765464, encodeId=e22c1e65464be, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Mar 02 08:42:00 CST 2012, time=2012-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879095, encodeId=ef8b18e9095b8, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Dec 25 22:42:00 CST 2011, time=2011-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296842, encodeId=87b2129684255, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317175, encodeId=8dc0131e17551, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605621, encodeId=bce2160562189, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=)]
    2011-11-07 fengyi812

    #EMA#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1765464, encodeId=e22c1e65464be, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Mar 02 08:42:00 CST 2012, time=2012-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879095, encodeId=ef8b18e9095b8, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Dec 25 22:42:00 CST 2011, time=2011-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296842, encodeId=87b2129684255, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317175, encodeId=8dc0131e17551, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605621, encodeId=bce2160562189, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Nov 07 14:42:00 CST 2011, time=2011-11-07, status=1, ipAttribution=)]
    2011-11-07 ms3994565386320060

    #Med#

    0

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