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Diabetologia:1997-2011年澳大利亚2型糖尿病诊断年龄对死亡率的影响

2018-05-31 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于1997-2011年澳大利亚2型糖尿病诊断年龄对死亡率的影响的研究。 目前的证据表明,2型糖尿病可能对那些早期诊断(疾病持续时间较长)的患者产生更大的影响,但目前数据有限。研究人员研究了2型糖尿病诊断年龄对15年以上全因和特定病死率的影响。 研究人员审查了1997年至2011年在国家糖尿病服务计划(NDSS)上登记的743,

近日,国际杂志 《Diabetologia》上在线发表一项关于1997-2011年澳大利亚2糖尿病诊断年龄对死亡率的影响的研究。

目前的证据表明,2糖尿病可能对那些早期诊断(疾病持续时间较长)的患者产生更大的影响,但目前数据有限。研究人员研究了2糖尿病诊断年龄对15年以上全因和特定病死率的影响。

研究人员审查了1997年至2011年在国家糖尿病服务计划(NDSS)上登记的743,7092型糖尿病患者的数据。通过将NDSS与国家死亡指数联系起来得出死亡率数据,确定了由心血管疾病(CVD),癌症和所有其他原因导致的全因死亡率和死亡率。使用泊松回归模型对性别,当前年龄,诊断年龄,糖尿病病程和日历时间的死亡率进行建模。

NDSS的登记中位年龄为60.2岁(四分位间距[IQR] 50.9-69.5),中位随访时间为7.2年(IQR 3.4-11.3)。诊断的中位年龄为58.6岁(IQR 49.4-67.9)。在720万人年的随访期间共发生115,363人死亡。在糖尿病诊断后的第一个1.8年中,全因死亡率和癌症死亡率下降,CVD死亡率不变。所有死亡率随着年龄呈指数增长。2型糖尿病的早期诊断(疾病持续时间较长)与全因死亡风险较高有关,主要由CVD死亡率驱动。10年前的诊断(相当于糖尿病病程长10年)与全因死亡风险增加1.2-1.3倍,CVD死亡风险增加1.6倍有关。男性和女性的效果相似。对于因癌症(所有癌症和结肠直肠癌和肺癌)导致的死亡率,研究人员发现早期诊断2型糖尿病与较年长时的诊断相比死亡率更低。

研究人员的研究结果表明,年轻发病的2型糖尿病会增加死亡风险,而这主要是因为早期心血管死亡率增加。因此,延迟2型糖尿病发作的努力可能会降低死亡率。

原始出处:

Lili Huo, Dianna J. Magliano, Fanny Rancièreet al. Impact of age at diagnosis and duration of type 2 diabetes on mortality in Australia 1997–2011

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    2018-06-02 惠映实验室

    学习了.谢谢分享.

    0

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    2018-06-02 yfjms

    学习

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