Am J Epidemiol：夜班或增加男性患癌症风险

2012年10月16日来自蒙特利尔大学等处的研究者通过研究揭示了，加夜班或增加男性患癌症风险。相关研究刊登于国际杂志Journal of Epidemiology，这项研究首次阐述了夜班和男性患前列腺癌、肺癌等癌症风险之间的关系。

长期的夜班或直接导致睡眠激素-褪黑激素产量的降低，并且诱导其生理学改变，进而刺激肿瘤的生成及发育。褪黑激素一般在半夜分泌产生，其在激素和免疫系统功能维持上扮演着重要的作用，研究者Marie这样说。

尽管发现夜班可以增加一些列的癌症风险，但是研究者仍然对于夜班促进癌症发生风险的关系及原因非常感兴趣。理论上来讲，长期持续的夜班将会增加癌症风险，但是研究者的结果并没有证实这一趋势。

研究者分析了在1970至1985年间职业暴露及癌症相关的一些数据，这些数据包括来自3137名在医院被诊断为癌症的35岁至70岁的男性患者，对照组为512个健康个体，通过分析研究表明，夜班和癌症风险增加直接相关。随着研究的进行，研究者表示，许多影响因子或许会影响人们，使得他们适应夜班生活，另有研究也揭示了夜班和前列腺癌的关系，未来还会有很多的研究涉及夜班和个体的健康相关的研究。

与癌症相关的拓展阅读：

• Onco & Cancer Res：袁增强等Hippo信号通路和癌症及细胞衰老研究获进展
• EBM：以崭新之生物医学造影技术研究癌症发展模式
• Am J Epidemiol：用体质指数判定癌症风险或需重新思考
• Nat Chem Biol：探究O-葡萄糖转移酶在癌症糖尿病等疾病中的作用
• CEBP：癌症幸存者生活质量或受影响  更多信息请点击：有关癌症更多资讯

Night Work and the Risk of Cancer Among Men

Night work might influence cancer risk, possibly via suppression of melatonin release. In a population-based case-control study conducted in Montreal, Quebec, Canada, between 1979 and 1985, job histories, including work hours, were elicited from 3,137 males with incident cancer at one of 11 anatomic sites and from 512 controls. Compared with men who never worked at night, the adjusted odds ratios among men who ever worked at night were 1.76 (95% confidence interval (CI): 1.25, 2.47) for lung cancer, 2.03 (95% CI: 1.43, 2.89) for colon cancer, 1.74 (95% CI: 1.22, 2.49) for bladder cancer, 2.77 (95% CI: 1.96, 3.92) for prostate cancer, 2.09 (95% CI: 1.40, 3.14) for rectal cancer, 2.27 (95% CI: 1.24, 4.15) for pancreatic cancer, and 2.31 (95% CI: 1.48, 3.61) for non-Hodgkin's lymphoma. Equivocal evidence or no evidence was observed for cancers of the stomach (odds ratio (OR) = 1.34, 95% CI: 0.85, 2.10), kidney (OR = 1.42, 95% CI: 0.86, 2.35), and esophagus (OR = 1.51, 95% CI: 0.80, 2.84) and for melanoma (OR = 1.04, 95% CI: 0.49, 2.22). There was no evidence of increasing risk with increasing duration of night work, with risks generally being increased across all duration categories. Results suggest that night work may increase cancer risk at several sites among men.