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CLIN CHEM：血浆尿酸盐，癌症发病率和全因死亡率间的关系

2017-06-07 MedSci MedSci原创

血浆尿酸盐癌症全因死亡率
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根据观察，高血浆尿酸盐与癌症的高风险相关。研究人员使用孟德尔随机化设计来测试高浓度血浆尿酸盐与观察性和遗传性高癌症发生率和全因死亡率相关的假说。研究人员对哥本哈根总体人口研究的86210个人中使用血浆尿酸盐和尿酸溶质载体家族2成员9（SLC2A9）rs7442295基因型进行观察和遗传分析。癌症和死亡率终点来自国家癌症和死亡登记。使用Cox回归，精细和灰色竞争风险回归和工具变量分析计算癌症和全因死

近日，国际杂志CLINICAL CHEMISTRY上在线发表一项关于血浆尿酸盐，癌症发病率和全因死亡率的研究。

根据观察，高血浆尿酸盐与癌症的高风险相关。研究人员使用孟德尔随机化设计来测试高浓度血浆尿酸盐与观察性和遗传性高癌症发生率和全因死亡率相关的假说。研究人员对哥本哈根总体人口研究的86210个人中使用血浆尿酸盐和尿酸溶质载体家族2成员9（SLC2A9）rs7442295基因型进行观察和遗传分析。癌症和死亡率终点来自国家癌症和死亡登记。使用Cox回归，精细和灰色竞争风险回归和工具变量分析计算癌症和全因死亡率的发生率和风险。

癌症患者平均随访时间为3.9年，全因死亡4.9年，3243人诊断为癌症，3978人死亡。观察到50％的血浆尿酸盐与多因素调整后的风险比相关，癌症发生率为1.11（95％CI，1.05-1.18），全因死亡率为1.07（1.01-1.13）。SLC2A9 rs7442295的每个A等位基因与9％的血浆尿酸盐相关，癌症发病率为1.07（1.01-1.14），全因死亡率为1.07（1.02-1.13）。在工具变量分析中，基因确定的50％高血浆尿酸盐的优势比为1.22（1.02-1.47），癌症发病率为1.49（1.13-1.93），全因死亡率为1.49（1.13-1.93）。

研究表明，高血浆尿酸盐在观察上和遗传学上均与高发病率和全因死亡率相关性较高，且存在明显的因果关系。

原始出处：

Camilla J. Kobylecki, Shoaib Afzal, Børge G. et.al. Plasma Urate, Cancer Incidence, and All-Cause Mortality: A Mendelian Randomization Study. Clinical Chemistry Jun 2017, 63 (6).

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    2017-08-28 lifestar

    #发病率#

    0

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    2018-05-14 ms6832696159214430

    #尿酸盐#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1823345, encodeId=350a182334522, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Mon Aug 28 14:02:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992514, encodeId=67c41992514b6, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Mon May 14 16:02:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251471, encodeId=9def12514e1fd, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Fri Jun 09 12:02:00 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208029, encodeId=289620802931, content=这个结论靠谱么？, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Jun 08 07:21:23 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208008, encodeId=22a520800864, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Thu Jun 08 07:01:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207862, encodeId=969e20e862ea, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Jun 07 21:37:29 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-09 lvliquan

    #全因死亡率#

    0

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    2017-06-08 飛歌

    这个结论靠谱么？

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1823345, encodeId=350a182334522, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Mon Aug 28 14:02:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992514, encodeId=67c41992514b6, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Mon May 14 16:02:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251471, encodeId=9def12514e1fd, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Fri Jun 09 12:02:00 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208029, encodeId=289620802931, content=这个结论靠谱么？, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Jun 08 07:21:23 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208008, encodeId=22a520800864, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Thu Jun 08 07:01:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207862, encodeId=969e20e862ea, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Jun 07 21:37:29 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-08 海棠胜雪

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1823345, encodeId=350a182334522, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Mon Aug 28 14:02:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992514, encodeId=67c41992514b6, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Mon May 14 16:02:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251471, encodeId=9def12514e1fd, content=<a href='/topic/show?id=874529332ba' target=_blank style='color:#2F92EE;'>#全因死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29332, encryptionId=874529332ba, topicName=全因死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Fri Jun 09 12:02:00 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208029, encodeId=289620802931, content=这个结论靠谱么？, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Jun 08 07:21:23 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208008, encodeId=22a520800864, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Thu Jun 08 07:01:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207862, encodeId=969e20e862ea, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Jun 07 21:37:29 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 changjiu

    学习，谢谢分享

    0

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