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Diabetologia：怀孕期间肥胖妇女妊娠期糖尿病代谢分析

2017-10-23 MedSci MedSci原创

糖尿病代谢分析
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产前肥胖和相关妊娠糖尿病（GDM）在世界范围内正在逐年增加。虽然预先存在的胰岛素抵抗与肥胖妇女的GDM有关，但可靠的代谢途径仍然研究较少。近日，国际杂志 《Diabetologia》上在线发表一项关于怀孕期间肥胖妇女妊娠期糖尿病代谢分析的研究。研究人员的目标是在OGTT诊断之前10周和诊断时比较有无GDM的肥胖孕妇血清中代谢状况。

产前肥胖和相关妊娠糖尿病（GDM）在世界范围内正在逐年增加。虽然预先存在的胰岛素抵抗与肥胖妇女的GDM有关，但可靠的代谢途径仍然研究较少。近日，国际杂志 《Diabetologia》上在线发表一项关于怀孕期间肥胖妇女妊娠期糖尿病代谢分析的研究。研究人员的目标是在OGTT诊断之前10周和诊断时比较有无GDM的肥胖孕妇血清中代谢状况。 在这项前瞻性队列研究中，研究人员调查了646名女性，其中198名发展为GDM，这是英国妊娠改善饮食和活动试验（UPBEAT）的二次分析，同时这也是一项针对肥胖孕妇的复杂生活方式干预的多中心随机对照试验。校正多变量回归分析进行多次测试，并对包括研究干预在内的适当混杂因素进行解释，将GDM肥胖妇女与非GDM肥胖女性进行比较。研究人员分析了在时间点1（平均孕龄17周0天）和时间点2（平均孕龄27周5天，OGTT检测时间）血清，血浆或全血中的163种分析物，包括来自目标NMR代谢组的147种，并在组间进行了比较。 研究发现，与没有GDM的女性相比，发展GDM的女性观察到多个显著性差异（假发现率校正p值<0.05）。大多数在诊断前是明显的。与没有GDM的妇女相比

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    2018-05-12 ms5439512287675881

    #BET#

    0

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    2018-08-13 ms9608593228839890

    #DIA#

    0

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    2018-07-10 guguangxiang

    #糖尿病代谢#

    0

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    2017-10-25 wjcjjian

    #妊娠期#

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    2017-10-25 shenxlcyp

    #妊娠期糖尿病#

    0

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    2017-10-23 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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