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Immunotherapy:益生菌提取物的鼻腔滴注能够抑制试验过敏性鼻炎

2019-09-23 AlexYang MedSci原创

过敏性鼻炎(AR)是一种常见的疾病。AR的治疗效果仍旧需要改善。最近,有研究人员评估了局部益生菌提取物给药对抑制试验性AR的效果情况。研究人员将上皮细胞(ECs)与丁酸梭菌提取物(CBe)共培养提高IL-10的表达,并建立了小鼠AR模型来评估CBe对AR的影响。研究发现,CBe能够显著的诱导IL-10在ECs中的表达。而B细胞与CBe处理的ECs共培养也能够显著的增加B细胞(iB-10)中IL-1

过敏性鼻炎(AR)是一种常见的疾病。AR的治疗效果仍旧需要改善。最近,有研究人员评估了局部益生菌提取物给药对抑制试验性AR的效果情况。

研究人员将上皮细胞(ECs)与丁酸梭菌提取物(CBe)共培养提高IL-10的表达,并建立了小鼠AR模型来评估CBe对AR的影响。研究发现,CBe能够显著的诱导IL-10在ECs中的表达。而B细胞与CBe处理的ECs共培养也能够显著的增加B细胞(iB-10)中IL-10的表达。另外,iB10细胞在抑制效应CD4+ t细胞增殖中具有免疫抑制功能。包含CBe的鼻滴液治疗能够有效的抑制试验小鼠的AR。

最后,研究人员指出,局部CBe给药能够有效的抑制试验性AR。

原始出处:

Zeng XH, Yang G, Liu JQ et al. Nasal instillation of probiotic extracts inhibits experimental allergic rhinitis. Immunotherapy. 03 Sep 2019

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    2019-09-25 mnda
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    2019-09-24 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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    2019-09-24 yjs木玉

    好好好好好好

    0

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    2019-09-24 深海的鱼

    学习学习学习

    0

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