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Respir Res:改善COPD患者运动能力 长效支气管扩张剂表现棒棒哒!

2018-02-12 王淳 环球医学

2018年1月,发表在《Respir Res》上的一项系统评价和meta分析,对长效支气管扩张剂在改善慢性阻塞性肺病(COPD)患者运动能力方面的情况进行了考察。

2018年1月,发表在《Respir Res》上的一项系统评价和meta分析,对长效支气管扩张剂在改善慢性阻塞性肺病(COPD)患者运动能力方面的情况进行了考察。

背景:研究人员开展了一项系统评价和meta分析,旨在评估长效支气管剂对COPD患者运动能力的疗效。

方法:结局指标根据不同的患者纳入标准和运动方法学,考察长效支气管剂(联合制剂,单一成分制剂)vs 安慰剂改善运动过程中耐力时间(ET)、深吸气量(IC)和呼吸困难的有效性。

结果:22项研究被认为符合分析。ET的加权平均值增加67 s(95%CI55-79)。对于运动期间的等时IC和呼吸困难,加权改善分别是195 ml(162-229)和-0.41个单位(-0.56至-0.27)。谷IC的增加是157 ml(138-175)。研究人员发现一个趋势,就ET而言,LAMA优于LABA。在11项报道功能残气量>纳入标准120%的研究中,ET的加权平均值增加94 s(65至123);但是,研究人员未发现ET与平均谷IC存在任何显着相关性(P: 0.593)。在5项采用步行作为运动方法学的研究中ET改善58 s(-4至121)。

结论:长效支气管扩张剂能改善COPD的运动能力。长效支气管扩张剂的主要作用似乎是减少基础IC而不是运动过程中的动态过度充气。在过度充气的患者中,ET提升效果似乎更高,步行或骑自行车也有类似的效果。

原始出处:

Di Marco F,et al. Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis. Respir Res. 2018 Jan 24;19(1):18. doi: 10.1186/s12931-018-0721-3.

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    2018-09-15 lsj637
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    2018-04-08 871538379

    Gold 也是如此建议

    0

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    2018-02-14 changjiu

    学习一下谢谢

    0

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    2018-02-14 gous
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