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Science:淋巴结转移并不是癌症扩散到其他器官的**方法

2017-07-07 Heather_z727 来宝网

癌症扩散是癌症最致命的方面,癌症扩散的传统模式是从原发肿瘤,扩散到附近的淋巴结,以及其他器官。然而,来自马萨诸塞州总医院(MGH)的研究人员发现这一扩散机制并不是在所有情况下都适用。他们的报告发表于7月7日的《科学》杂志中,研究人员描述发现,对于大多数结直肠癌患者来说,他们的肿瘤独立于任何淋巴结进行“遥远”转移。

癌症扩散是癌症最致命的方面,癌症扩散的传统模式是从原发肿瘤,扩散到附近的淋巴结,以及其他器官。然而,来自马萨诸塞州总医院(MGH)的研究人员发现这一扩散机制并不是在所有情况下都适用。他们的报告发表于7月7日的《科学》杂志中,研究人员描述发现,对于大多数结直肠癌患者来说,他们的肿瘤独立于任何淋巴结进行“遥远”转移。

研究人员表示:“我们的研究结果为远处转移提供了证据,证明淋巴结转移并不适用于所有甚至大多数结肠直肠癌。这些发现填补了我们对于癌症转移方面的重要空白,可能为结直肠癌的临床治疗提供新的可能性。”

此次研究是2014年的后续研究,先前的研究揭示了不同肿瘤在患者体内的发展和转移情况,此次研究发现,原发性和转移性肿瘤之间的关系。在此次研究的200份大肠癌样本中,35%的患者结果表明,原发肿瘤的淋巴结转移和远处转移都存在。而其余的65%患者的远处转移细胞类型不同与原发肿瘤,这一实验结果表明了,直结肠癌患者独立转移的类型。

研究人员表示:“我们怀疑淋巴结转移并不直接负责远处转移,现在我们需要调查临床结果,厘清远处转移和淋巴结转移的致病机制是否存在差异性,如果有差异,我们的分析可能成为未来有用的预后。”

原始出处:

Kamila Naxerova, Johannes G. Reiter, et al. Origins of lymphatic and distant metastases in human colorectal cancer. Science  07 Jul 2017: Vol. 357, Issue 6346, pp. 55-60 DOI: 10.1126/science.aai8515

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    2017-07-10 日月生辉

    非区域淋巴结转,既往视为远处转移,学习了!

    0

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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219889, encodeId=334d219889e6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Jul 08 09:29:35 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-09 jichang
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Jul 09 07:05:30 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220068, encodeId=3f4e22006800, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jul 08 21:35:59 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219951, encodeId=2708219951ef, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Jul 08 13:00:04 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219889, encodeId=334d219889e6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Jul 08 09:29:35 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-09 sodoo
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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219889, encodeId=334d219889e6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Jul 08 09:29:35 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-09 榄枷檬

    癌症扩散是癌症最致命的方面,癌症扩散的传统模式是从原发肿瘤,扩散到附近的淋巴结,以及其他器官。

    0

  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66028, encryptionId=7be06602886, topicName=淋巴结转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Sun Jul 09 14:36:00 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292991, encodeId=0155129299176, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Sun Jul 09 14:36:00 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220232, 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Jul 09 07:05:30 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220068, encodeId=3f4e22006800, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jul 08 21:35:59 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219951, encodeId=2708219951ef, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Jul 08 13:00:04 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219889, encodeId=334d219889e6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Jul 08 09:29:35 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-09 jet747

    重磅研究,学习了

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66028, encryptionId=7be06602886, topicName=淋巴结转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Sun Jul 09 14:36:00 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292991, encodeId=0155129299176, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Sun Jul 09 14:36:00 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220232, 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Jul 09 07:05:30 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220068, encodeId=3f4e22006800, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jul 08 21:35:59 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219951, encodeId=2708219951ef, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Jul 08 13:00:04 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219889, encodeId=334d219889e6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Jul 08 09:29:35 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 luominglian113

    学习了,谢谢分享

    0

  9. 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Jul 09 07:05:30 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220068, encodeId=3f4e22006800, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sat Jul 08 21:35:59 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219951, encodeId=2708219951ef, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Jul 08 13:00:04 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219889, encodeId=334d219889e6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Jul 08 09:29:35 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 139****5926

    好好文章学习了

    0

  10. 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219889, encodeId=334d219889e6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Jul 08 09:29:35 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 半夏微凉

    谢谢分享,学习了

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