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Stroke:IVIM所示微血管灌注减少可预测动脉瘤破裂后迟发性脑缺血发生

2018-02-23 国际循环编辑部 国际循环

脑动脉瘤破裂后的近端动脉痉挛和迟发性脑缺血(DCI)可使大脑灌注及微血管灌注减少,并可显著增加发病率及死亡;而体素内不相干运动(IVIM)磁共振成像可用于评估微血管灌注情况。

脑动脉瘤破裂后的近端动脉痉挛和迟发性脑缺血(DCI)可使大脑灌注及微血管灌注减少,并可显著增加发病率及死亡;而体素内不相干运动(IVIM)磁共振成像可用于评估微血管灌注情况。近日,Stroke发表一项最新回归性队列研究探讨了IVIM所示微血管灌注减少是否有助于识别近端动脉血管痉挛及DCI患者。

研究共计对动脉瘤破裂治疗后采用IVIM行脑磁共振成像的61例连续脑动脉瘤破裂的患者(女性11例)进行回顾性分析,通过电子病历收集人口统计学、治疗、影像学及结局方面的数据。研究的主要终点是发生需血管内治疗的、伴近端动脉血管痉挛的DCI,次要终点包括6个月时的死亡率及临床结局。

结果发现,与未发生DCI者(6例)相比,出现需行血管内治疗的DCI患者(10例)的年龄、神经功能状态及合并症均无差异;IVIM灌注分数f更低[(0.09±0.03) vs.(0.13±0.01),P=0.03],扩散系数D更低[(0.82±0.05) mm2/s vs. (0.92±0.07×10−3)mm2/s,P=0.003],血流相关指标fD*也更低[(1.18±0.40)mm2/s vs. (1.83±0.40×10−3)mm2/s,P=0.009],但IVIM假性扩散系数D*无差异[(0.011±0.002)mm2/s vs.(0.013±0.005) mm2/s,P=0.4]。此外,研究发现,两组患者6个月时的死亡率及临床结局无差异。

上述结果提示,IVIM所示的灌注分数及血流相关指标fD*的减少与脑动脉瘤破裂后DCI及近端动脉痉挛的发生具有相关性。

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  4. [GetPortalCommentsPageByObjectIdResponse(id=2021288, encodeId=ee79202128809, content=<a href='/topic/show?id=699610138b7' target=_blank style='color:#2F92EE;'>#IVIM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10138, encryptionId=699610138b7, topicName=IVIM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Sun Apr 01 05:28:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707944, encodeId=65551e07944e6, content=<a href='/topic/show?id=65e5946002d' target=_blank style='color:#2F92EE;'>#迟发性脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94600, encryptionId=65e5946002d, topicName=迟发性脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=919531514804, createdName=小华子, createdTime=Tue Jul 17 16:28:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034404, encodeId=473620344049f, content=<a href='/topic/show?id=45eb94588cd' target=_blank style='color:#2F92EE;'>#迟发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94588, encryptionId=45eb94588cd, topicName=迟发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri May 04 08:28:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293303, encodeId=acf52933032e, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Mar 05 21:14:25 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292973, encodeId=907e2929e315, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Mar 04 19:32:28 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292093, encodeId=e30229209378, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Mar 01 21:36:48 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291477, encodeId=9c262914e706, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Feb 27 20:34:33 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290859, encodeId=7a4e29085981, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Feb 25 21:15:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289217, encodeId=0bcf128921e23, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365339, encodeId=0ddf1365339a8, content=<a href='/topic/show?id=2a2150e76fd' target=_blank style='color:#2F92EE;'>#微血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50776, encryptionId=2a2150e76fd, topicName=微血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-03-05 杨柳青青

    签到学习了--

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2021288, encodeId=ee79202128809, content=<a href='/topic/show?id=699610138b7' target=_blank style='color:#2F92EE;'>#IVIM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10138, encryptionId=699610138b7, topicName=IVIM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Sun Apr 01 05:28:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707944, encodeId=65551e07944e6, content=<a href='/topic/show?id=65e5946002d' target=_blank style='color:#2F92EE;'>#迟发性脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94600, encryptionId=65e5946002d, topicName=迟发性脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=919531514804, createdName=小华子, createdTime=Tue Jul 17 16:28:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034404, encodeId=473620344049f, content=<a href='/topic/show?id=45eb94588cd' target=_blank style='color:#2F92EE;'>#迟发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94588, encryptionId=45eb94588cd, topicName=迟发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri May 04 08:28:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293303, encodeId=acf52933032e, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Mar 05 21:14:25 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292973, encodeId=907e2929e315, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Mar 04 19:32:28 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292093, encodeId=e30229209378, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Mar 01 21:36:48 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291477, encodeId=9c262914e706, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Feb 27 20:34:33 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290859, encodeId=7a4e29085981, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Feb 25 21:15:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289217, encodeId=0bcf128921e23, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365339, encodeId=0ddf1365339a8, content=<a href='/topic/show?id=2a2150e76fd' target=_blank style='color:#2F92EE;'>#微血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50776, encryptionId=2a2150e76fd, topicName=微血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-03-04 杨柳青青

    签到学习了--

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2021288, encodeId=ee79202128809, content=<a href='/topic/show?id=699610138b7' target=_blank style='color:#2F92EE;'>#IVIM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10138, encryptionId=699610138b7, topicName=IVIM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Sun Apr 01 05:28:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707944, encodeId=65551e07944e6, content=<a href='/topic/show?id=65e5946002d' target=_blank style='color:#2F92EE;'>#迟发性脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94600, encryptionId=65e5946002d, topicName=迟发性脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=919531514804, createdName=小华子, createdTime=Tue Jul 17 16:28:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034404, encodeId=473620344049f, content=<a href='/topic/show?id=45eb94588cd' target=_blank style='color:#2F92EE;'>#迟发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94588, encryptionId=45eb94588cd, topicName=迟发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri May 04 08:28:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293303, encodeId=acf52933032e, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Mar 05 21:14:25 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292973, encodeId=907e2929e315, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Mar 04 19:32:28 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292093, encodeId=e30229209378, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Mar 01 21:36:48 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291477, encodeId=9c262914e706, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Feb 27 20:34:33 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290859, encodeId=7a4e29085981, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Feb 25 21:15:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289217, encodeId=0bcf128921e23, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365339, encodeId=0ddf1365339a8, content=<a href='/topic/show?id=2a2150e76fd' target=_blank style='color:#2F92EE;'>#微血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50776, encryptionId=2a2150e76fd, topicName=微血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-03-01 杨柳青青

    签到学习了--

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2021288, encodeId=ee79202128809, content=<a href='/topic/show?id=699610138b7' target=_blank style='color:#2F92EE;'>#IVIM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10138, encryptionId=699610138b7, topicName=IVIM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Sun Apr 01 05:28:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707944, encodeId=65551e07944e6, content=<a href='/topic/show?id=65e5946002d' target=_blank style='color:#2F92EE;'>#迟发性脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94600, encryptionId=65e5946002d, topicName=迟发性脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=919531514804, createdName=小华子, createdTime=Tue Jul 17 16:28:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034404, encodeId=473620344049f, content=<a href='/topic/show?id=45eb94588cd' target=_blank style='color:#2F92EE;'>#迟发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94588, encryptionId=45eb94588cd, topicName=迟发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri May 04 08:28:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293303, encodeId=acf52933032e, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Mar 05 21:14:25 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292973, encodeId=907e2929e315, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Mar 04 19:32:28 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292093, encodeId=e30229209378, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Mar 01 21:36:48 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291477, encodeId=9c262914e706, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Feb 27 20:34:33 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290859, encodeId=7a4e29085981, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Feb 25 21:15:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289217, encodeId=0bcf128921e23, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365339, encodeId=0ddf1365339a8, content=<a href='/topic/show?id=2a2150e76fd' target=_blank style='color:#2F92EE;'>#微血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50776, encryptionId=2a2150e76fd, topicName=微血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-27 杨柳青青

    签到学习了--

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2021288, encodeId=ee79202128809, content=<a href='/topic/show?id=699610138b7' target=_blank style='color:#2F92EE;'>#IVIM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10138, encryptionId=699610138b7, topicName=IVIM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Sun Apr 01 05:28:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707944, encodeId=65551e07944e6, content=<a href='/topic/show?id=65e5946002d' target=_blank style='color:#2F92EE;'>#迟发性脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94600, encryptionId=65e5946002d, topicName=迟发性脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=919531514804, createdName=小华子, createdTime=Tue Jul 17 16:28:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034404, encodeId=473620344049f, content=<a href='/topic/show?id=45eb94588cd' target=_blank style='color:#2F92EE;'>#迟发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94588, encryptionId=45eb94588cd, topicName=迟发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri May 04 08:28:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293303, encodeId=acf52933032e, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Mon Mar 05 21:14:25 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292973, encodeId=907e2929e315, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Mar 04 19:32:28 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292093, encodeId=e30229209378, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Mar 01 21:36:48 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291477, encodeId=9c262914e706, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Tue Feb 27 20:34:33 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290859, encodeId=7a4e29085981, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Sun Feb 25 21:15:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289217, encodeId=0bcf128921e23, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365339, encodeId=0ddf1365339a8, content=<a href='/topic/show?id=2a2150e76fd' target=_blank style='color:#2F92EE;'>#微血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50776, encryptionId=2a2150e76fd, topicName=微血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=669d219, createdName=mgqwxj, createdTime=Sun Feb 25 11:28:00 CST 2018, time=2018-02-25, status=1, ipAttribution=)]
    2018-02-25 杨柳青青

    签到学习了--

    0

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    2018-02-25 mgqwxj

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