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Int J Cardiol:白蛋白尿能更好地预测房颤患者栓塞事件的发生

2016-07-26 phylis 译 MedSci原创

背景:在管理非瓣膜性心房颤动患者(NVAF)上,准确的危险分层是重要。然而,一个队列研究显示,根据CHA2DS2-VASc评分真正意义上的“低风险”者,每年缺血性卒中发生率在1.61%。研究者旨在找出更多的指标,评估其预测血栓事件(TE)的能力。方法:研究者将58例TE患者分为血栓形成组,157例非TE患者分为非血栓组。对这些患者的临床参数进行单因素非条件Logistic回归分析筛选风险的界值点。

背景:在管理非瓣膜性心房颤动患者(NVAF)上,准确的危险分层是重要。然而,一个队列研究显示,根据CHA2DS2-VASc评分真正意义上的“低风险”者,每年缺血性卒中发生率在1.61%。研究者旨在找出更多的指标,评估其预测血栓事件(TE)的能力。

方法:研究者将58例TE患者分为血栓形成组,157例非TE患者分为非血栓组。对这些患者的临床参数进行单因素非条件Logistic回归分析筛选风险的界值点。然后,研究者形成了CHA2DS2-VASc-UA2评分,并与CHA2DS2-VASc评分进行比较。

结果:血栓组UA的平均值明显高于非血栓组(0.1 VS 0.0g/l,P<0.01)。非条件Logistic回归分析结果表明,UA的OR为40.98(95%CI:3.58-468.88,P<0.01)。最佳分界点为0.03g/L, UA曲线下面积(AUC)0.700。ROC曲线分析结果表明, CHA2DS2-VASc-UA2评分AUC高于CHA2DS2-VASc评分(0.873 vs 0.860)。

结论:UA≥0.03g/L是非瓣膜性房颤患者的TE的独立预测因素。与CHA2DS2-VASc评分相比,CHA2DS2-VASc-UA2评分可能能更好地预测TE的发生。

原始出处:

He H, Guo J, Zhang A. The value of urine albumin in predicting thromboembolic events for patients with non-valvular atrial fibrillation. Int J Cardiol. 2016 Jul 11


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    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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    2016-07-27 珙桐
  6. [GetPortalCommentsPageByObjectIdResponse(id=2029180, encodeId=e2e02029180e9, content=<a href='/topic/show?id=f2c862006ea' target=_blank style='color:#2F92EE;'>#栓塞事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62006, encryptionId=f2c862006ea, topicName=栓塞事件)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/6F20312C71B4B22F603078C6DCFA72CE/100, createdBy=d3572500071, createdName=ms306040998833292, createdTime=Fri Apr 07 07:12:00 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781721, encodeId=2eaa1e81721fd, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Jul 01 08:12:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145346, encodeId=563f145346b0, content=好文值得点赞!继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:15:28 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135085, encodeId=fc911350850e, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 17:17:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304590, encodeId=3b091304590bc, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Wed Jul 27 15:12:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377095, encodeId=5f4013e70955d, content=<a href='/topic/show?id=ae99e1769f9' target=_blank style='color:#2F92EE;'>#白蛋白尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71769, encryptionId=ae99e1769f9, topicName=白蛋白尿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Wed Jul 27 15:12:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614314, encodeId=68881614314f8, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jul 27 15:12:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
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