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Sci Rep：仿生纤维内矿化胶原或是一种优良的骨再生支架材料

2017-09-13 MedSci MedSci原创

仿生纤维内矿化胶原骨再生
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由于其结构和功能与天然骨骼相似，仿生纤维内矿化胶原（IMC）是有前途的骨再生支架。本研究旨在使用大面积骨缺损的小型猪模型评估伴有自体牙周膜干细胞（PDLSCs）的IMC的骨再生潜能。研究人员使用仿生自下而上方法制造具有骨样亚原纤维纳米结构的大孔IMC。在小型猪颅骨上建立了不愈合的全厚缺陷，将植入有自体PDLSCs的IMC和羟基磷灰石（HA）支架植入这些缺陷。应用计算机断层扫描成像，组织学染色和原子

由于其结构和功能与天然骨骼相似，仿生纤维内矿化胶原（IMC）是有前途的骨再生支架。本研究旨在使用大面积骨缺损的小型猪模型评估伴有自体牙周膜干细胞（PDLSCs）的IMC的骨再生潜能。

研究人员使用仿生自下而上方法制造具有骨样亚原纤维纳米结构的大孔IMC。在小型猪颅骨上建立了不愈合的全厚缺陷，将植入有自体PDLSCs的IMC和羟基磷灰石（HA）支架植入这些缺陷。应用计算机断层扫描成像，组织学染色和原子力显微镜评估数量，微/纳米结构，以及植骨12周后新骨的机械性能。

结果显示，与HA相比，IMC显示出优异的再生特性，其特征在于具有正常结构和血管形成的新骨结构大量沉积。免疫组织化学显示，runt相关转录因子2和转录因子Osterix在IMC形成的新骨中高度表达。此外，由IMC形成的新骨的纳米结构和纳米力学与天然骨相似。

总之，该研究结果为基于IMC的骨移植物的未来临床应用提供了有力的证据。

原始出处：

Ci Zhang, Boxi Yan, Zhen Cui, et al., Bone regeneration in minipigs by intrafibrillarly-mineralized collagen loaded with autologous periodontal ligament stem cells. Sci Rep. 2017; 7: 10519. Published online 2017 Sep 5. doi: 10.1038/s41598-017-11155-7

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1721304, encodeId=8a3e1e2130423, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Nov 01 04:13:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775795, encodeId=336b1e75795d2, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Mon Feb 26 08:13:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244207, encodeId=42fa24420e98, content=学习了学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Fri Sep 15 07:23:02 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472086, encodeId=9a5814e208638, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Sep 15 07:13:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243697, encodeId=5a9124369ec5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Sep 13 23:42:23 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243595, encodeId=8a5d2435957e, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Sep 13 17:54:20 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-11-01 yahu

    #矿化#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1721304, encodeId=8a3e1e2130423, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Nov 01 04:13:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775795, encodeId=336b1e75795d2, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Mon Feb 26 08:13:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244207, encodeId=42fa24420e98, content=学习了学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Fri Sep 15 07:23:02 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472086, encodeId=9a5814e208638, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Sep 15 07:13:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243697, encodeId=5a9124369ec5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Sep 13 23:42:23 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243595, encodeId=8a5d2435957e, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Sep 13 17:54:20 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2018-02-26 tidiq

    #支架材料#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1721304, encodeId=8a3e1e2130423, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Nov 01 04:13:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775795, encodeId=336b1e75795d2, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Mon Feb 26 08:13:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244207, encodeId=42fa24420e98, content=学习了学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Fri Sep 15 07:23:02 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472086, encodeId=9a5814e208638, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Sep 15 07:13:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243697, encodeId=5a9124369ec5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Sep 13 23:42:23 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243595, encodeId=8a5d2435957e, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Sep 13 17:54:20 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-15 hfuym10906

    学习了学习了学习了学习了学习了学习了学习了学习了

    0

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    2017-09-15 lsj630

    #骨再生#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1721304, encodeId=8a3e1e2130423, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Nov 01 04:13:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775795, encodeId=336b1e75795d2, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Mon Feb 26 08:13:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244207, encodeId=42fa24420e98, content=学习了学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Fri Sep 15 07:23:02 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472086, encodeId=9a5814e208638, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Sep 15 07:13:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243697, encodeId=5a9124369ec5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Sep 13 23:42:23 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243595, encodeId=8a5d2435957e, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Sep 13 17:54:20 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-13 184****9840

    学习了受益匪浅

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1721304, encodeId=8a3e1e2130423, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Nov 01 04:13:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775795, encodeId=336b1e75795d2, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Mon Feb 26 08:13:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244207, encodeId=42fa24420e98, content=学习了学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Fri Sep 15 07:23:02 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472086, encodeId=9a5814e208638, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Sep 15 07:13:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243697, encodeId=5a9124369ec5, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Sep 13 23:42:23 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243595, encodeId=8a5d2435957e, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Wed Sep 13 17:54:20 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-13 tanxingdoctor

    学习啦!谢谢分享!

    0

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