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Cell Matab:研究发现保护细胞远离有害脂肪的关键角色!

2017-08-03 枫丹白露 来宝网

哈佛大学公共卫生学院和霍华德休斯医学研究所的一项新研究揭示了关键的生产脂肪酶如何帮助保护细胞免受有毒形式的脂肪。



【研究确定了保护细胞免受有毒脂肪的酶】哈佛大学公共卫生学院和霍华德休斯医学研究所的一项新研究揭示了关键的生产脂肪酶如何帮助保护细胞免受有毒形式的脂肪。

新发现有助于更全面地了解与肥胖相关的常见代谢疾病(例如2型糖尿病,脂肪肝疾病和心力衰竭)的基础生物学,并可能导致如何更好地治疗这些疾病的新见解。

该研究将在线发表在细胞代谢上。

哈佛大学遗传与复杂疾病教授罗伯特·法雷斯(Robert Farese)教授说:“我们对这些发现感到兴奋 - 他们解决了一个谜团,并展示了脂肪合成如何保护细胞免受功能障碍和疾病的伤害。

研究的主要作者是哈佛研究员Chandramohan Chitraju。

研究人员研究了脂肪分解过程中细胞内甘油三酸酯(一种脂肪)发生的情况,甘油三酯被分解为脂肪酸并将其转运到身体其他组织中的能力。几十年来,科学家们想知道为什么一些甘油三酯在分解成脂肪酸之后,以甘油三酸酯的形式回到细胞中,这个过程被称为“再酯化”。

通过研究小鼠和人类细胞中的过程,研究人员发现为什么:再酯化有助于保护称为内质网(ER)的关键细胞器。 ER有助于产生细胞产物如蛋白质和脂质,并可能被脂肪酸损害,但不能被甘油三酯损伤。研究人员还发现,称为DGAT1(二酰基甘油酰基转移酶)的酶对于再酯化过程至关重要,作为一种细胞监督者,以确保有毒的脂肪酸远离ER。

哈佛大学遗传与复杂疾病教授Tobias Walther表示,为了更好地了解肥胖症时细胞被脂肪压倒的情况,我们首先要了解系统如何正常处理脂质的波动。我们的研究结果将有希望引发关于如何预防肥胖的健康后果的新思路。”

哈佛大学的Niklas Mejhert也是合作者。

原始出处

Chandramohan Chitraju, Niklas Mejhert, Joel T. Haas, et al. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysi. Cell Metabolism, doi: 10.1016/j.cmet.2017.07.012, published 1 August 2017.

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    2018-01-03 维他命
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    2017-08-05 bbjsj_1981
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    2017-08-04 flyingzyx

    学习了,谢谢。

    0

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    2017-08-03 nannanxyy

    长知识

    0

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    2017-08-03 1dd8aa01m06(暂无匿称)

    学习学习学习

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    2017-08-03 131****1460

    学习了受益匪浅

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