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Biomed Res Int:光动力疗法对种植体周微生物的作用

2018-10-17 MedSci MedSci原创

种植体周围炎是导致种植失败的晚期并发症之一,且与牙周病细菌的特定微生物感染相关。本研究旨在使用光动力疗法在种植体周围炎治疗后使用TaqMan PCR检测来评估不同种植体表面与牙龈卟啉单胞菌、福赛坦氏菌和齿密垢螺旋体数量之间的关系。 将具有四种不同表面处理的48颗牙种植体(M:机械加工;SA:喷砂酸蚀;S:1μm溅射HA涂覆;和P:等离子喷涂HA涂覆)植入至六只比格犬中。在种植体周围炎诱导9个

种植体周围炎是导致种植失败的晚期并发症之一,且与牙周病细菌的特定微生物感染相关。本研究旨在使用光动力疗法在种植体周围炎治疗后使用TaqMan PCR检测来评估不同种植体表面与牙龈卟啉单胞菌、福赛坦氏菌和齿密垢螺旋体数量之间的关系。

将具有四种不同表面处理的48颗牙种植体(M:机械加工;SA:喷砂酸蚀;S:1μm溅射HA涂覆;和P:等离子喷涂HA涂覆)植入至六只比格犬中。在种植体周围炎诱导9个月后,使用了分口设计;在对照组进行清创处理,使用塑料刮匙进行翻瓣清创OFD,实验组使用二极管激光(Ga Al As 830-nm)的光动力疗法PDT。在接下来的2周内,在每个种植体侧,使用低强度激光治疗LLLT(10mW)处理,持续6秒。使用纸尖收集种植体周围的微生物样品,并在种植体周围炎治疗之前、治疗后立即和治疗后5个月使用TaqMan PCR进行分析。

结果显示,两种治疗方式均显示从基线到治疗后所有细菌计数显著降低(P <0.0001)。治疗后立即至治疗后5个月细菌计数增加(P <0.0001);然而,5个月后的细菌计数明显低于基线。与OFD相比,PDT减少牙龈卟啉单胞菌的强度较福赛坦氏菌和齿密垢螺旋体更强。对于福赛坦氏菌,植体表面处理具有最大的效果,差异也具有统计学意义(P = 0.02)。

综上所述,该研究结果表明,PDT和OFD通过减少细菌数量在种植体周围炎治疗中具有明显的益处。存在对治疗方式具有不同反应的细菌复合物表明使用组合的清创方法用于种植体周围炎治疗。

原始出处:

Madi M, Alagl AS. The Effect of Different Implant Surfaces and Photodynamic Therapy on Periodontopathic Bacteria Using TaqMan PCR Assay following Peri-Implantitis Treatment in Dog Model. Biomed Res Int. 2018 Jul 4;2018:7570105. doi: 10.1155/2018/7570105. eCollection 2018.

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    2019-08-16 huangdf
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    2019-05-14 sunylz
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