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JCEM:体重波动与糖尿病、心血管疾病和死亡率

2018-12-01 xing.T MedSci原创

由此可见,体重波动与死亡率相关。此外,体重波动对发生糖尿病的影响取决于基线时肥胖状况。

已有研究发现体重波动与冠状动脉疾病患者的较高死亡率和血管事件有关。然而,关于体重波动与一般人群健康相关的结局之间关系的数据非常有限。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员评估了韩国基因组和流行病学研究中的韩国人群体重波动是否与糖尿病血管事件以及死亡率之间存在关系。研究人员通过平均连续变异性(ASV)计算个体体重波动,并且收集了3678名参与者的健康相关结局,每2年收集一次,共收集了16年。

研究人员发现体重ASV较大的参与者肥胖较多,并且基线时血压和HbA1c水平高于体重ASV较小的个体。体重ASV每增加一单位与死亡率增加有关(HR为1.46,95%CI为1.32-1.62,P<0.001)。然而,体重ASV与糖尿病发病率之间的关联似乎受基线体重指数(BMI)的影响; 在BMI<25 kg/m2的个体中具有负性效应(HR为1.36,95%CI为1.11-1.65,P=0.003),在BMI≥25kg/m2的个体中具有保护性效应(HR为0.76,95%CI为0.60-0.95,P=0.014)。体重ASV与心血管事件之间没有关联。

由此可见,体重波动与死亡率相关。此外,体重波动对发生糖尿病的影响取决于基线时肥胖状况。

原始出处:

Tae Jung Oh,et al.Body-weight fluctuation and incident diabetes mellitus, cardiovascular disease, and mortality: a 16-year prospective cohort study.J Clin Endocrinol Metab. 2018. https://doi.org/10.1210/jc.2018-01239

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    2019-11-10 achengzhao
  2. [GetPortalCommentsPageByObjectIdResponse(id=2063218, encodeId=5fbb2063218fb, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sun Nov 10 05:14:00 CST 2019, time=2019-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777836, encodeId=32ef1e77836c0, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Jan 22 06:14:00 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356473, encodeId=96da3564e3a6, content=非常实际的临床经验,值得学习与借鉴,获益匪浅,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Dec 26 17:59:17 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498502, encodeId=cbdc1498502bb, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Dec 03 01:14:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042075, encodeId=916f10420e5a2, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Dec 01 13:14:00 CST 2018, time=2018-12-01, status=1, ipAttribution=)]
    2019-01-22 smallant2015
  3. [GetPortalCommentsPageByObjectIdResponse(id=2063218, encodeId=5fbb2063218fb, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sun Nov 10 05:14:00 CST 2019, time=2019-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777836, encodeId=32ef1e77836c0, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Jan 22 06:14:00 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356473, encodeId=96da3564e3a6, content=非常实际的临床经验,值得学习与借鉴,获益匪浅,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Wed Dec 26 17:59:17 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498502, encodeId=cbdc1498502bb, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Dec 03 01:14:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042075, encodeId=916f10420e5a2, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Dec 01 13:14:00 CST 2018, time=2018-12-01, status=1, ipAttribution=)]
    2018-12-26 13718711b3m

    非常实际的临床经验,值得学习与借鉴,获益匪浅,谢谢分享!

    0

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    2018-12-01 misszhang

    谢谢MedSci提供最新的资讯

    0

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