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Mol Pharm:中药治疗类风湿关节炎的作用机制——系统药理学研究

2017-08-13 MedSci MedSci原创

作为一种发病率和死亡率不断增加的慢性炎症和血管疾病,类风湿性关节炎(RA)是一种病因未明的慢性、以炎性滑膜炎为主的系统性疾病,临床特征主要为关节滑膜组织增生和单核细胞浸润过度累积,常导致关节畸形、残疾,最终导致骨与软骨的破坏。中医(TCM)在正确有效地处理如RA这样的炎症性关节病方面有着丰富的历史,中医认为这些疾病的治疗需从一个综合性、整体的观点出发。然而,如果只采用常规中医疗法的话,它的“多成分

作为一种发病率和死亡率不断增加的慢性炎症和血管疾病,类风湿性关节炎(RA)是一种病因未明的慢性、以炎性滑膜炎为主的系统性疾病,临床特征主要为关节滑膜组织增生和单核细胞浸润过度累积,常导致关节畸形、残疾,最终导致骨与软骨的破坏。

中医(TCM)在正确有效地处理如RA这样的炎症性关节病方面有着丰富的历史,中医认为这些疾病的治疗需从一个综合性、整体的观点出发。然而,如果只采用常规中医疗法的话,它的“多成分”和“多目标”的特点使得很难从系统的角度来解读其治疗RA的分子机制。

在本研究中,我国的研究人员采用了一种结合了药物ADME筛选模型、药物的靶向性和网络药理学研究的-创新的系统药理学的方法,探索中药治疗RA的作用机理。

研究人员在7个RA相关的草药的研究中发现了117个活性化合物和85个关键分子靶点,主要涉及四条信号通路,即VEGF、PI3K-Akt、TLR和T细胞受体信号通路。此外,研究人员还得到了活性成分、靶蛋白和信号通路之间的网络关系,进一步揭示了这些草药的药理特性。此外,研究人员采用MM/PBSA方法探讨了化合物与其受体之间的结合亲和力,以及配体与靶蛋白之间的相互作用。体外配体结合试验证实了药物靶标相互作用和MD结果的可靠性。

活性化合物间的高亲和力和良好抑制作用表明,这些草药治疗RA时的潜在治疗作用可能是通过对相关蛋白的调控而产生的,这进一步验证了药物靶标相互作用和研究人员基于网络的分析方法的合理性和可靠性。

本研究不仅有助于了解中药的作用机制和从植物中发现新的治疗类风湿关节炎的药物,还为现代医学治疗复杂疾病提供了一种新的潜在途径。

原始出处:

Wang J, Li Y,et al.Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action for Herbal Medicines in Treating Rheumatoid Arthritis.Mol Pharm. 2017 Aug 3. doi: 10.1021/acs.molpharmaceut.7b00505. [Epub ahead of print]

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    2018-07-26 jj000001
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time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233646, encodeId=f3bc23364697, content=学习一下!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Tue Aug 15 05:52:19 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-23 kalery

    好文章学习了

    0

  4. 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    2017-08-16 ren1mw

    学习一下!谢谢分享

    0

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  8. 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time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233646, encodeId=f3bc23364697, content=学习一下!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Tue Aug 15 05:52:19 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 lmm397
  9. 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time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233646, encodeId=f3bc23364697, content=学习一下!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Tue Aug 15 05:52:19 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 Jackie Li

    学习

    0

  10. 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time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233646, encodeId=f3bc23364697, content=学习一下!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Tue Aug 15 05:52:19 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 ren1mw

    学习一下!谢谢分享!

    0

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ANN RHEUM DIS:2010 ACR/EULAR类风湿关节炎分类标准中典型类风湿关节炎侵蚀的作用

少数早期关节炎患者仅基于侵蚀标准被归类为RA。

ANN RHEUM DIS:外周血显性B细胞受体克隆可以预测类风湿性关节炎风险个体的起病

外周血显性BCR克隆可以高准确性地预测RA风险个体临床症状体征的发生。

ANN RHEUM DIS:类风湿关节炎维持SB4治疗或从依那西普转为SB4的长期疗效和安全性

SB4对RA患者2年内是有效和耐受性良好的。SB4/SB4和ETN/SB4组的功效、安全性和免疫原性相当。

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