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Eur Respir J:空气污染与特发性肺纤维化发病率的关系分析!

2018-01-28 xing.T MedSci原创

虽然仍需要验证性研究来进行证实,但该研究结果揭示了暴露于交通污染与IPF发生发展之间存在潜在联系。

特发性肺纤维化(IPF)的急性加重和恶化与暴露于臭氧(O3)、二氧化氮(NO2)和颗粒物有关,但慢性暴露于空气污染也可能影响IPF的发病率。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员调查了2005年至2010年之间意大利北部慢性暴露于O3、NO2和空气动力学直径小于10 μM(PM10)的颗粒物与IPF发病率之间的相关性。

研究人员从时空模型中获得每日预测的PM10浓度,以及从固定的监测站得到每小时的NO2和O3浓度。研究人员确定了每个污染物都有均匀暴露的区域,并创建了负二项式模型来评估通过管理数据库得到的区域特异性IPF发病率与整体平均和季节性PM10、NO2和8小时最大O3浓度之间的相关性。

在使用未经调整的模型中,研究人员发现NO2浓度每增加10µg*m-3与IPF发病率增加7.93%(95%可信区间为0.36-16.08%)至8.41%(95%可信区间为-0.23-17.80%)之间有关,受不同季节的影响。在调整潜在的混杂因素后,估计的效应在程度上相似,但可信区间较大。

虽然仍需要验证性研究来进行证实,但该研究结果揭示了暴露于交通污染与IPF发生发展之间存在潜在联系。

原始出处:

Sara Conti,et al. The association between air pollution and the incidence of idiopathic pulmonary fibrosis in Northern Italy.Eur Respir J.2018. http://erj.ersjournals.com/content/51/1/1700397

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    2018-01-29 1217558dm72暂无昵称

    henhao

    0

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    2018-01-28 祝您健康

    学习

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    2018-01-28 Y—xianghai

    学习了新知识

    0

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