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UROLOGY:透明细胞肾细胞癌患者的组织和血清中5′-tRNA表达异常

2018-02-22 xuyihan MedSci原创

在各种恶性肿瘤中,RNA片段都是异常的。本研究旨在确定 5′-tRNA在透明细胞肾细胞癌患者的组织和血清中的表达情况。

在各种恶性肿瘤中,RNA片段都是异常的。本研究旨在确定 5′-tRNA在透明细胞肾细胞癌患者的组织和血清中的表达情况。

研究人员在生物库中收集了透明细胞肾细胞癌和非恶性疾病患者的组织和血清样本。然后分离了来自95个透明细胞肾细胞癌患者和50个正常人的肾组织的总RNA,以及27个透明细胞性肾细胞癌和13个非恶性泌尿系统疾病的患者的血清RNA。

结果发现在透明细胞肾细胞癌组织内,所有的5′t-RNA表达都受到抑制,这表明其具有潜在的肿瘤抑制作用。此外,研究人员注意到部分患者其临床病理参数数值较高。透明细胞肾细胞癌患者5′-tRNA-Arg-CCT,5′-tRNA-Glu-CTC和5′-tRNA-Lys-TTT半流通相比对照组处于较低水平,表明其可能可以作为非侵入性生物标志物。

结论
透明细胞肾细胞癌患者的5′t-RNA可能是诊断和预后的生物标志物。5′t-RNA可能具有抑制肿瘤的作用,然而这需要进一步的研究来证实。

原始出处:
Chenming Zhao.et al.5′-tRNA Halves are Dysregulated in Clear Cell Renal Cell Carcinoma.UROLOGY.2018.

本文由梅斯医学(MedSci)原创编译整理,转载需授权!


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    2018-02-24 liao1622
  4. [GetPortalCommentsPageByObjectIdResponse(id=1978645, encodeId=e72519e864567, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Mon Apr 02 17:00:00 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793435, encodeId=01141e93435b9, content=<a href='/topic/show?id=d96c155e526' target=_blank style='color:#2F92EE;'>#RNA表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15575, encryptionId=d96c155e526, topicName=RNA表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72bf2500198, createdName=小小小向日葵, createdTime=Sat Jul 21 04:00:00 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486556, encodeId=518e14865560d, content=<a href='/topic/show?id=cd401e84239' target=_blank style='color:#2F92EE;'>#tRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17842, encryptionId=cd401e84239, topicName=tRNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89bf8152050, createdName=liao1622, createdTime=Sat Feb 24 12:00:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290016, encodeId=d4f0290016f8, content=在各种恶性肿瘤中.RNA片段都是异常的.本研究旨在确定5′-tRNA在透明细胞肾细胞癌患者的组织和血清中的表达情况., beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Feb 22 22:32:44 CST 2018, time=2018-02-22, status=1, ipAttribution=)]
    2018-02-22 有备才能无患

    在各种恶性肿瘤中.RNA片段都是异常的.本研究旨在确定5′-tRNA在透明细胞肾细胞癌患者的组织和血清中的表达情况.

    0

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