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Eur Respir J:5-羟色胺能抗抑郁药的使用与老年COPD患者发病率和死亡率的关系

2018-07-28 xing.T MedSci原创

由此可见,刚开始使用5-羟色胺能抗抑郁药与COPD老年人呼吸相关发病率和死亡率小幅但显著增加有关。需要进一步的研究来澄清所观察到的相关性是否存在因果关系,还是未解决的混淆所致。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员旨在评估选择性5-羟色胺再摄取抑制剂(SSRI)或5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)药物的使用与老年慢性阻塞性肺病(COPD)患者呼吸相关发病率和死亡率之间的关系。

这是一项基于人群的使用加拿大安大略省的健康管理数据进行的回顾性队列研究。受试者年龄≥66岁,经过医生确诊为COPD(n=131718)的个体被纳入研究。服用SSRI/SNRI的受试者经倾向得分与对照者相关的协变量以1:1进行匹配,最大限度地减少潜在的混淆。

在倾向评分匹配的社区居民中,与非使用者相比,服用SSRI/SNRI的受试者患COPD或肺炎的住院率(风险比(HR)为1.15,95%CI为1.05-1.25)、COPD或肺炎急诊就诊率(HR为1.13,95%CI为1.03-1.24)、COPD或肺炎相关死亡率(HR为1.26,95%CI为1.03-1.55)和全因死亡率(HR为1.20,95%CI为1.11-1.29)显著较高。此外,刚开始服用SSRI/SNRI药物与对照的长期护理居民相比呼吸特异性和全因死亡率更高。

由此可见,刚开始使用5-羟色胺能抗抑郁药与COPD老年人呼吸相关发病率和死亡率小幅但显著增加有关。需要进一步的研究来澄清所观察到的相关性是否存在因果关系,还是未解决的混淆所致。

原始出处:

Nicholas T. Vozoris,et al. Serotonergic antidepressant use and morbidity and mortality among older adults with COPD. Eur Respir J. 2018. http://erj.ersjournals.com/content/52/1/1800475

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    2018-10-19 wetgdt
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    2018-08-05 小小小麦兜

    学习了

    0

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    2018-08-04 liumin1987

    ***

    0

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    2018-07-29 gous
  8. [GetPortalCommentsPageByObjectIdResponse(id=1778878, encodeId=36df1e78878cb, content=<a href='/topic/show?id=b10014088a' target=_blank style='color:#2F92EE;'>#5-羟色胺能抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1408, encryptionId=b10014088a, topicName=5-羟色胺能抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sat Oct 13 20:49:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722497, encodeId=17551e2249715, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Fri Oct 19 18:49:00 CST 2018, time=2018-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823478, encodeId=dd5b18234e81d, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sat Jan 26 15:49:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779254, encodeId=b3671e79254eb, content=<a href='/topic/show?id=b10014088a' target=_blank style='color:#2F92EE;'>#5-羟色胺能抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1408, encryptionId=b10014088a, topicName=5-羟色胺能抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu May 30 03:49:00 CST 2019, time=2019-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336675, encodeId=93663366e503, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/f3d88083d8829740786bed95c22464d1/e325f3af93bb747a620d16c209094d69.jpg, createdBy=9efb2014947, createdName=小小小麦兜, createdTime=Sun Aug 05 19:25:17 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336322, encodeId=6bec3363221b, content=***, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sat Aug 04 10:57:28 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488834, encodeId=6ff41488834d8, content=<a href='/topic/show?id=69675090ca' target=_blank style='color:#2F92EE;'>#COPD患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5090, encryptionId=69675090ca, topicName=COPD患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852e8475198, createdName=gous, createdTime=Sun Jul 29 23:49:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492227, encodeId=6d80149222e2e, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Jul 29 23:49:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334680, encodeId=460333468006, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Jul 28 09:04:55 CST 2018, time=2018-07-28, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1778878, encodeId=36df1e78878cb, content=<a href='/topic/show?id=b10014088a' target=_blank style='color:#2F92EE;'>#5-羟色胺能抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1408, encryptionId=b10014088a, topicName=5-羟色胺能抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sat Oct 13 20:49:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722497, encodeId=17551e2249715, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Fri Oct 19 18:49:00 CST 2018, time=2018-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823478, encodeId=dd5b18234e81d, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sat Jan 26 15:49:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779254, encodeId=b3671e79254eb, content=<a href='/topic/show?id=b10014088a' target=_blank style='color:#2F92EE;'>#5-羟色胺能抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1408, encryptionId=b10014088a, topicName=5-羟色胺能抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu May 30 03:49:00 CST 2019, time=2019-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336675, encodeId=93663366e503, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/f3d88083d8829740786bed95c22464d1/e325f3af93bb747a620d16c209094d69.jpg, createdBy=9efb2014947, createdName=小小小麦兜, createdTime=Sun Aug 05 19:25:17 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336322, encodeId=6bec3363221b, content=***, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sat Aug 04 10:57:28 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488834, encodeId=6ff41488834d8, content=<a href='/topic/show?id=69675090ca' target=_blank style='color:#2F92EE;'>#COPD患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5090, encryptionId=69675090ca, topicName=COPD患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852e8475198, createdName=gous, createdTime=Sun Jul 29 23:49:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492227, encodeId=6d80149222e2e, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Jul 29 23:49:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334680, encodeId=460333468006, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sat Jul 28 09:04:55 CST 2018, time=2018-07-28, status=1, ipAttribution=)]
    2018-07-28 kafei

    了解一下谢谢

    0

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