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Nat Commun:日本发现肥胖相关基因

2013-09-13 koo 生物360

   日前,日本京都府立医科大学等机构的科学家们发现与肥胖有关的一个基因,若抑制该基因表达,即使摄入高脂肪食物,也不容易变胖。相关研究论文刊登在了近期出版的《自然-通讯》上。【原文阅读】 研究人员发现,这种名为“ARIA”的基因具有妨碍脂肪燃烧的功能。在实验鼠实验中,研究人员发现,“ARIA”基因表达被抑制的实验鼠不容易变胖,即使它们与正常实验鼠一起连续14周食用高脂肪食物,其皮下和内

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日前,日本京都府立医科大学等机构的科学家们发现与肥胖有关的一个基因,若抑制该基因表达,即使摄入高脂肪食物,也不容易变胖。相关研究论文刊登在了近期出版的《自然-通讯》上。【原文阅读】

研究人员发现,这种名为“ARIA”的基因具有妨碍脂肪燃烧的功能。在实验鼠实验中,研究人员发现,“ARIA”基因表达被抑制的实验鼠不容易变胖,即使它们与正常实验鼠一起连续14周食用高脂肪食物,其皮下和内脏脂肪的量也只有后者的三分之一至二分之一。

在喂食普通食物的实验中,研究人员发现,虽然两组实验鼠的体重没有出现差别,但是“ARIA”基因表达受抑制的实验鼠的血糖值上升受到遏制,研究人员认为这表明它们不容易患糖尿病

研究人员表示,如果能研发出抑制这种基因作用的新药,就有可能找到治疗肥胖的新疗法。

此前也曾有研究发现,某种基因缺陷也会导致肥胖,即使摄入少量食物也容易肥胖,即人们通常所说的“喝凉水都长肉”。针对不同体质的人群,未来有望进行有针对性的基因介入疗法。


原文阅读
Akakabe Y, Koide M, Kitamura Y, Matsuo K, Ueyama T, Matoba S, Yamada H, Miyata K, Oike Y, Ikeda K.Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.Nat Commun. 2013 Sep 11;4:2389. doi: 10.1038/ncomms3389.

    

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    2013-09-22 liuli5079
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