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eLife:骨骼肌也有生物钟?药物无需靶向,大脑即可调控睡眠质量!

2017-08-14 TJU 转化医学网

加州大学洛杉矶分校(UCLA)的科学家首次证实:一个脑外基因可以控制睡眠不足后的恢复能力。这个令人惊讶的发现意味着将来药物无需进入大脑便可以调控睡眠质量。这个研究将为睡眠障碍治疗提供新的潜在靶点。

加州大学洛杉矶分校(UCLA)的科学家首次证实:一个脑外基因可以控制睡眠不足后的恢复能力。这个令人惊讶的发现意味着将来药物无需进入大脑便可以调控睡眠质量。这个研究将为睡眠障碍治疗提供新的潜在靶点。

科学家指出:增加小鼠骨骼肌中调节睡眠模式的关键基因Bmal1的水平,小鼠的睡眠不足恢复能力显着提高。

UCLA综合生物学和生理学副教授兼该研究资深作者Ketema Paul说:“这是我们第一次意识到肌肉的重要性,起初我们并不相信,所以重复了几次实验,终于意识到这不是意外,这是真实的。”

研究结果即将发表在《eLife》期刊,研究首次揭示骨骼肌中存在生物钟,还可以与大脑通信。那些包括照顾新生儿或者工作时间不允许等在内所导致睡眠不足的人均可能成为这项研究的受益者。

神经生物学家兼UCLA脑科研究员Paul强调:慢性睡眠剥夺会增加心脏病,中风,糖尿病,传染病以及其他疾病的风险,克服睡眠不足可能会降低患上这些疾病的风险。然而这项研究报告指出骨骼肌中Bmal1的升高可能会帮助机体克服睡眠不足。

在研究中,研究人员使用分子遗传技术敲除了小鼠大脑和体内Bmal1基因,从而影响其恢复睡眠剥夺的能力。当研究人员恢复骨骼肌中的Bmal1基因时,小鼠能够迅速从睡眠不足中得以恢复;当恢复大脑中的Bmal1基因时,令人惊讶的是小鼠的睡眠剥夺恢复能力并没有增强。增加骨骼肌中该基因的表达水平也使得老鼠在睡眠剥夺较长时间后不再困倦。研究人员通过插入额外的Bmal1基因来提高Bmal1的表达水平。

“研究数据表明,Bmal1不仅负责睡眠障碍后的恢复能力,而且Bmal1在骨骼肌中的表达对该过程也是负责的。”Paul说。“当我们上调骨骼肌中Bmal1表达量时,小鼠对睡眠障碍的忍耐力也随之增加,这表明骨骼肌直接与大脑通信。”

此外,研究人员使小鼠保持清醒24小时,用脑电图测量了小鼠的脑活动,发现与没有额外的Bmal1的小鼠相比,Bmal1过度表达的小鼠的脑部活动更加活跃。在睡眠剥夺实验之后的24小时内,Bmal1增加的小鼠的睡眠需求显着少于其他小鼠。

同时,研究人员利用分子技术将小鼠骨骼肌中的Bmal1基因切除,发现这种切除损害了小鼠的睡眠剥夺恢复能力,这些老鼠睡着了。

研究人员没有观察到增加小鼠骨骼肌中Bmal1的表达量会对小鼠造成任何负面影响。

为什么睡眠研究人员现在才发现骨骼肌中Bmal1的重要性,Bmal1也是人类基因?

Paul解释道:“过去研究人员花费了大量时间在大脑中寻找相关基因。”

Bmal1是一种调控其他基因开启和关闭的关键基因。Paul说:“在未来,科学家们会研发一种能增加肌肉中Bmal1水平的药物,甚至直接提高Bmal1表达以更好地增强与大脑昼夜节律钟之间的通信。”
原始出处:
Ketema N Paul,Allison J Brager,Lennisha Pinckney.et al.Bmal1 function in skeletal muscle regulates sleep.eLife

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    2018-06-14 膀胱癌
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    2018-06-14 clmlylxy
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    2017-08-15 meiliwuxian

    学习一下。看来睡眠和运动可能也有关联

    0

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    2017-08-15 半夏微凉

    学习了谢谢分享

    0

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    2017-08-14 惠映实验室

    学习了谢谢。

    0

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总之,这些研究结果提供的证据表明FGF19是骨骼肌质量调节中的一种新因子,以及它对肌肉萎缩具有治疗的潜力。

Diabetes:运动增加人体骨骼肌胰岛素敏感性的新机制

因此,急性运动增加肌肉胰岛素敏感性,是通过同时增加胰岛素刺激的微血管灌注和上调肌肉TBC1D4的分子信号和糖原合酶水平。这将一方面改善葡萄糖转运,另一方面,增加了摄取和利用葡萄糖的能力。

Diabetes:2型糖尿病患者miRNA-29表达可以影响骨骼肌葡萄糖和脂质代谢!

总的来说,该研究揭示了miR-29作为胰岛素刺激葡萄糖代谢和脂质过氧化的重要调节因子,与人体生理功能和2型糖尿病具有相关性。

Hypertension:骨骼肌脂肪含量与高血压发生有关!

该研究结果显示,在非洲血统的男性中降低的肌肉衰减与新发高血压之间存在相关性,并且独立于一般和中心性肥胖以及胰岛素抵抗。需要进一步研究以调整炎症、内脏和其他异位脂肪组织累积,并在其他人群样本中来确认这些研究结果。

Mol Cell:浙江大学孟卓贤研究组揭示骨骼肌细胞调控全身葡萄糖稳态的新机制

近日,国际著名学术杂志《Cell》子刊《Molecular Cell》在线发表了浙江大学医学院孟卓贤研究员和美国密歇根大学林建德研究组合作的一篇研究论文,论文题为“Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis”。研究论文被选为当期封面文章,研究揭示了骨骼肌细胞中存在一条

Diabetes Care:2型糖尿病患者抗阻力训练中骨骼肌微血管参与改善血糖控制!

由此可见,RT可以改善OGC刺激的肌肉MBF和血糖控制,这表明MBF在RT改善的血糖控制发挥了作用。

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