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Algernon正在探索将Ifenprodil用作COVID-19冠状病毒的新型疗法,小鼠实验中该药物具有显着降低急性肺损伤的作用

2020-03-08 MedSci原创 MedSci原创

Algernon Pharmaceuticals公司近日宣布,正在探索使用NP-120(Ifenprodil)作为冠状病毒COVID-19新型治疗方法的潜力。

Algernon Pharmaceuticals公司近日宣布,正在探索使用NP-120(Ifenprodil)作为冠状病毒COVID-19新型治疗方法的潜力。一项最新的独立研究发现,在对H5N1感染小鼠的研究中,Ifenprodil显着降低了急性肺损伤(ALI)并提高了生存能力。H5N1是迄今为止已知的最致命的流感病毒,死亡率超过50%。

该公司认为Ifenprodil有可能成为最严重冠状病毒患者的一线治疗药物,并且还可以降低患者的发病率。目前,冠状病毒的总体预测死亡率约为4%。Algernon公司认为Ifenprodil可用于COVID-19的治疗是基于历史动物研究而非人类试验。

尽管根据当前数据得出的总死亡率为4%,但冠状病毒感染的患者有时会出现严重的肺部并发症,包括肺部浸润、浑浊和呼吸窘迫综合症。除了全身性类固醇疗法外,临床医生几乎没有可用于治疗这些患者的药物,Ifenprodil可能作为一种新的有效治疗选择,来降低炎性浸润和由此产生的纤维化反应。

原始出处:

https://www.firstwordpharma.com/node/1706342?tsid=4

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    2020-03-10 tastas
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    2020-03-10 HNYYM
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    2020-03-10 sunylz
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