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Allergy:在哮喘病人中,糖皮质激素可以通过STAT通路抑制ILC2频率和活性

2018-03-26 AlexYang MedSci原创

第2组先天免疫淋巴细胞(ILC2)与哮喘存在着紧密的相关性。然而,哮喘病人中,在糖皮质激素对ILC2s的影响上却没有前瞻性的研究。最近,有研究人员进行了一个前瞻性的研究并且评估了哮喘病人在糖皮质激素治疗后ILC2的活性。研究人员对哮喘病人和哮喘伴随过敏性鼻炎的病人进行了为期3个月的糖皮质激素治疗。研究发现,在治疗1个月后,病人病情得到良好的控制;治疗3个月后,高ILC2水平显著的下降。来自过敏性病

第2组先天免疫淋巴细胞(ILC2)与哮喘存在着紧密的相关性。然而,哮喘病人中,在糖皮质激素对ILC2s的影响上却没有前瞻性的研究。最近,有研究人员进行了一个前瞻性的研究并且评估了哮喘病人在糖皮质激素治疗后ILC2的活性。

研究人员对哮喘病人和哮喘伴随过敏性鼻炎的病人进行了为期3个月的糖皮质激素治疗。研究发现,在治疗1个月后,病人病情得到良好的控制;治疗3个月后,高ILC2水平显著的下降。来自过敏性病人的外周血单核细胞产生了大量的IL-5、IL-13和IL-9,这些因子对IL-25、IL-33和IL-2具有应答;但是糖皮质激素治疗能够显著的降低上述因子的水平。更多的是,ILC2s是IL-5、IL-13和IL-9产生明显的来源。并且糖皮质激素治疗能够逆转它们的高水平存在。另外,研究人员还证实了STAT3, STAT5, STAT6, JAK3 和 MEK信号通路在糖皮质激素治疗下,能够对ILC2活性进行调控。

最后,研究人员指出,这些数据表明了糖皮质激素治疗能够通过MEK/JAK-STAT信号通路调控ILC2s从而有效的治疗哮喘。他们的研究在过敏性疾病方面提供了一个糖皮质激素应用的新的理解。

原始出处:


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    2018-03-28 wqkm

    ^_^^_^^_^^_^

    0

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    2018-03-28 hb2008ye
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    2018-03-26 惠映实验室

    学习了.谢谢分享.

    0

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