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PNAS:生理压力、生物机能障碍与2型糖尿病

2014-10-22 Eurekalert Eurekalert

一项研究提出了在2型糖尿病、接触压力增加以及从压力中恢复的生物能力削弱之间的一种联系。流行病学研究已经提示了在2型糖尿病的发展与进程中的生理压力过程与生物机能障碍之间的一个联系,但是这种关系背后的机制仍不清楚。Andrew Steptoe及其同事探索了患2型糖尿病的人们是否遇到了高于平均水平的长期压力以及长期非稳态负荷,其迹象是对生理压力的生物应答与恢复的动态扰动。这组作者比较了

一项研究提出了在2型糖尿病、接触压力增加以及从压力中恢复的生物能力削弱之间的一种联系。流行病学研究已经提示了在2型糖尿病的发展与进程中的生理压力过程与生物机能障碍之间的一个联系,但是这种关系背后的机制仍不清楚。

Andrew Steptoe及其同事探索了患2型糖尿病的人们是否遇到了高于平均水平的长期压力以及长期非稳态负荷,其迹象是对生理压力的生物应答与恢复的动态扰动。这组作者比较了140名患2型糖尿病的成年人与280名年龄、性别以及收入匹配的没有糖尿病的受试者的心血管、神经内分泌、炎症与代谢系统这4种生物系统的指标。

这些发现提示,患2型糖尿病的人们对压力做出响应的时候恢复正常血压、心律以及胆固醇的能力被削弱。2型糖尿病的受试者还比其他受试者表现出了更高水平的皮质醇和IL-6浓度、更大的抑郁和敌对症状,以及总体上更大的压力。这组作者说,这些发现提示了2型糖尿病背后的可能的原因。

原始出处:

Andrew Steptoea,1, Ruth A. Hacketta, Antonio I. Lazzarinoa, Sophie Bostocka, Roberto La Marcab, Livia A. Carvalhoa, and Mark Hamera.Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load.PNAS doi: 10.1073/pnas.1410401111

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    2015-06-08 ljjj1053

    好好学习学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=26311, encodeId=3d742631100, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 14:05:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20518, encodeId=d29d2051867, content=控制好糖尿病可能提高肝硬化患者的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:05:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1855645, encodeId=36511855645a4, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Tue Sep 29 14:31:00 CST 2015, time=2015-09-29, status=1, ipAttribution=)]
    2015-04-11 x35042875

    控制好糖尿病可能提高肝硬化患者的预后。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=26311, encodeId=3d742631100, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 14:05:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20518, encodeId=d29d2051867, content=控制好糖尿病可能提高肝硬化患者的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:05:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1855645, encodeId=36511855645a4, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Tue Sep 29 14:31:00 CST 2015, time=2015-09-29, status=1, ipAttribution=)]
    2015-09-29 drwjr
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