Baidu
map

心血管

订阅

MedSci主页 / 所有栏目 / 心血管

Circ Heart Fail：去肾交感神经术在动脉高压治疗中的潜在作用

2021-03-17 MedSci原创 MedSci原创

去肾交感神经术动脉高压射血分数保留的心力衰竭
关注

去肾交感神经术(RDN)在未控制的动脉高压的HFpEF患者中的临床和血流动力学意义

动脉高压是射血分数保留的心力衰竭(HFpEF)患者最常见的并发症，通过相关的主动脉僵硬和脉动负荷增加介导的不量血流动力。

该研究目的是探究去肾交感神经术(RDN)在未控制的动脉高压的HFpEF患者中的临床和血流动力学意义。

回顾性分析了2011~2018年期间在同一中心接受RDN的患者，分为HFpEF组(n=99)和无心衰组(n=65)。心脏磁共振成像测量每搏量指数和主动脉扩张性，超声心动图评价左心室(LV)收缩和舒张特性。

RDN术后各参数的变化

基线时，与无心衰患者相比，HFpEF患者的每搏量指数(中位值 40 vs 33 mL/m2，p=0.002)和脉压(69 vs 61 mmHg，p<0.001)均更高，但左室-左室射血分数(18 vs 24 mL，p=0.007)和主动脉扩张性(1.5 vs 2.7×10-3mmHg，p=0.013)均较低。

主动脉扩张性的变化

RDN术后，HFpEF患者和无心衰患者收缩压的降低幅度相当(-9 mmHg，p<0.001)。HFpEF患者RDN术后的每搏量指数(-3 mL/m2，p=0.011)降低，主动脉扩张性(0.20×10-3mmHg，p=0.007)和收缩期僵硬度(p<0.001)增加。左心室舒张期僵硬度、左心室充盈压、NT-proBNP均显著降低。

总结图

总之，与非心衰患者相比，HFpEF患者RDN术后的每搏量指数、血管和左心室僵硬度增加均更明显。RDN术后，HFpEF患者的血流动力学以及收缩和舒张期左室僵硬度均部分恢复正常，提示RDN可能是治疗动脉高血压和HFpEF的一种潜在策略。

原始出处：

Kresoja Karl-Patrik,Rommel Karl-Philipp,Fengler Karl et al. Renal Sympathetic Denervation in Patients With Heart Failure With Preserved Ejection Fraction. Circ Heart Fail, 2021, undefined: CIRCHEARTFAILURE120007421.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1967326, encodeId=6d8a196e3266b, content=<a href='/topic/show?id=03513e279e5' target=_blank style='color:#2F92EE;'>#去肾交感神经术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37279, encryptionId=03513e279e5, topicName=去肾交感神经术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Tue Dec 28 19:40:51 CST 2021, time=2021-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822260, encodeId=5d1b18222605e, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Jun 06 03:40:51 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925356, encodeId=7d9519253567c, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Nov 19 12:40:51 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357665, encodeId=6cb3135e665f4, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563423, encodeId=c637156342324, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-12-28 zjubiostat

    #去肾交感神经术#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1967326, encodeId=6d8a196e3266b, content=<a href='/topic/show?id=03513e279e5' target=_blank style='color:#2F92EE;'>#去肾交感神经术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37279, encryptionId=03513e279e5, topicName=去肾交感神经术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Tue Dec 28 19:40:51 CST 2021, time=2021-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822260, encodeId=5d1b18222605e, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Jun 06 03:40:51 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925356, encodeId=7d9519253567c, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Nov 19 12:40:51 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357665, encodeId=6cb3135e665f4, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563423, encodeId=c637156342324, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-06-06 shijzhiewnjhch

    #高压治疗#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1967326, encodeId=6d8a196e3266b, content=<a href='/topic/show?id=03513e279e5' target=_blank style='color:#2F92EE;'>#去肾交感神经术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37279, encryptionId=03513e279e5, topicName=去肾交感神经术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Tue Dec 28 19:40:51 CST 2021, time=2021-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822260, encodeId=5d1b18222605e, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Jun 06 03:40:51 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925356, encodeId=7d9519253567c, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Nov 19 12:40:51 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357665, encodeId=6cb3135e665f4, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563423, encodeId=c637156342324, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-11-19 jklm09

    #动脉高压#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1967326, encodeId=6d8a196e3266b, content=<a href='/topic/show?id=03513e279e5' target=_blank style='color:#2F92EE;'>#去肾交感神经术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37279, encryptionId=03513e279e5, topicName=去肾交感神经术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Tue Dec 28 19:40:51 CST 2021, time=2021-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822260, encodeId=5d1b18222605e, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Jun 06 03:40:51 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925356, encodeId=7d9519253567c, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Nov 19 12:40:51 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357665, encodeId=6cb3135e665f4, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563423, encodeId=c637156342324, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-03-19 zhaojie88

    #ART#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1967326, encodeId=6d8a196e3266b, content=<a href='/topic/show?id=03513e279e5' target=_blank style='color:#2F92EE;'>#去肾交感神经术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37279, encryptionId=03513e279e5, topicName=去肾交感神经术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Tue Dec 28 19:40:51 CST 2021, time=2021-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822260, encodeId=5d1b18222605e, content=<a href='/topic/show?id=9dad102285ed' target=_blank style='color:#2F92EE;'>#高压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102285, encryptionId=9dad102285ed, topicName=高压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Jun 06 03:40:51 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925356, encodeId=7d9519253567c, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Nov 19 12:40:51 CST 2021, time=2021-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357665, encodeId=6cb3135e665f4, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563423, encodeId=c637156342324, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 19 13:40:51 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-03-19 slcumt

    #HEART#

    0

相关资讯

JACC：去肾交感神经术意外发现

德国萨尔大学tephan H Schirmer等开展的一项小型研究提示，顽固性高血压患者在接受去肾交感神经术（RDN）治疗后，左室肥厚和舒张功能均有显著改善，且这些方面的获益与血压和心率变化无关 Schirmer兴奋地表示，"该研究结果的新奇之处在于，心脏形态上的改善与血液动力学改变无关。"他认为，如果这些结果能在大规模研究中获得证实，那么RDN可能会增添新的适应证，

EuroPCR2018：SPYRAL HTN-ON MED试验发布，经导管去肾交感神经术的又一里程碑式研究

昨日，在欧洲心血管介入会议（EuroPCR）2018年年会上，SPYRAL HTN-ON MED试验再次为经导管去肾交感神经术（RDN）加了“一把火”，研究表明：RDN可有效治疗轻中度高血压。

阜外医院用新方法RSD攻克顽固性高血压

 国家心血管病中心阜外医院在国内率先使用经CE批准上市的去肾交感神经射频消融专用导管系统（Ardian公司生产Simplicity射频消融导管），为4名顽固性高血压患者实施了去肾交感神经射频消融术，手术过程顺利，手术圆满成功。这种新的顽固性高血压介入治疗技术在医学上称为经导管射频消融去肾交感神经术（Catheter-basedrenalsympatheticdenervation，简称R

Symplicity HTN-3 后时代：经导管去肾交感神经术（RDN）研究新进展及未来方向

顽固性高血压（resistant hypertension）由于其严重的并发症，仍然是内科医生的一个重大挑战。据统计约有8％-18％的高血压患者属于顽固性高血压。经导管去肾交感神经术（renal sympathetic denervation, RDN）是近年来用于治疗顽固性高血压的新方法。Symplicity HTN- 1、Symp

Baidu
map
Baidu
map
Baidu
map