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Pancreas:牙周病可增加胰腺癌的发病风险

2015-10-19 MedSci MedSci原创

Pancreas:牙周病可增加机体胰腺癌的发病风险目前,公众逐渐认识到牙周病是系统性疾病的的一个危险因素,目前已知的相关的系统性疾病包括糖尿病、心血管疾病及癌症等。本研究旨在探究牙周病(牙龈炎,牙周炎及其他牙周性疾病)与胰腺癌之间的关系。研究共纳入139805名牙周炎患者以及75085名非牙周炎对照者。使用Cox比例风险回归模型对比两组研究对象胰腺癌的发病率。结果发现,牙周病与胰腺癌的发生呈正相关

目前,公众逐渐认识到牙周病是系统性疾病的的一个危险因素,目前已知的相关的系统性疾病包括糖尿病、心血管疾病及癌症等。本研究旨在探究牙周病(牙龈炎,牙周炎及其他牙周性疾病)与胰腺癌之间的关系。

研究共纳入139805名牙周炎患者以及75085名非牙周炎对照者。使用Cox比例风险回归模型对比两组研究对象胰腺癌的发病率。

结果发现,牙周病与胰腺癌的发生呈正相关关系(HR,1.55;95% [CI], 1.02-2.33)。二者之间的此种关系主要见于年龄在65岁及以上的老人中(HR,2.17;95% CI, 1.03-4.57),对于年龄小于65的研究对象则未发现二者之间存在此种关联(HR, 0.83; 95% CI, 0.52-1.34)。进一步的分析表明,牙周病是胰腺癌的一个独立危险因素,已知的胰腺癌的危险因素主要包括糖尿病高血压,过敏,病毒性肝炎,消化性溃疡,胰腺炎,慢性阻塞性肺病以及饮酒相关的疾病。

总而言之,该研究结果表明,牙周炎与胰腺癌的发病风险呈正相关关系。其潜在的生物学机制仍需进一步的研究以明确。

原始出处:

Chang JS, Tsai CR, Chen LT, Shan YS. Investigating the Association Between Periodontal Disease and Risk of Pancreatic Cancer. Pancreas. 2015 Oct 15.


友情提示:流行病学研究表明,中国成年人牙周病的发病率在90% 以上(其实说99%都不为过,谁牙龈没肿过啊,没注意没症状而已),早期牙周炎基础治疗便可达到很好的效果,当然防患于未然更好,定期口腔检查,定期“洗牙”,而且现在越来越多的研究表明牙周炎与全身多个系统性疾病相关,正如本文所写的一样,此外还有早产和低出生体重儿,肾病,高血压等,所以各位自己都掂量着吧,祝好!

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    2016-02-24 源源

    牙周病

    0

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    2016-02-24 源源

    不能收藏?

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1741838, encodeId=13431e418383e, content=<a href='/topic/show?id=653113e0852' target=_blank style='color:#2F92EE;'>#Pancreas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13708, encryptionId=653113e0852, topicName=Pancreas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a00434942797, createdName=ms6747015003810650, createdTime=Sun Jan 17 19:07:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65306, encodeId=021b65306fb, content=牙周病, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b6041668753, createdName=源源, createdTime=Wed Feb 24 01:55:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65307, encodeId=62086530e4c, content=不能收藏?, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b6041668753, createdName=源源, createdTime=Wed Feb 24 01:55:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55510, encodeId=0361555107b, content=牙有病引发全身病!高血压。糖尿病。胃病。姨腺炎等等。我就是受害者。对了肠道疾病。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Sun Jan 10 12:38:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47083, encodeId=dac84e08381, content=科普, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Dec 22 17:08:00 CST 2015, time=2015-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45488, encodeId=6d284548897, content=的确是真的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Thu Dec 10 16:34:00 CST 2015, time=2015-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41026, encodeId=d9824102628, content=应该大力科普!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25101619573, createdName=zhixue, createdTime=Sun Oct 25 11:46:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40078, encodeId=d773400e8e3, content=的确如此!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Wed Oct 21 18:21:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282233, encodeId=6eb2128223324, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Wed Oct 21 11:07:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450431, encodeId=0e2614504314b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Oct 21 11:07:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
    2016-01-10 1dd82894m82(暂无匿称)

    牙有病引发全身病!高血压。糖尿病。胃病。姨腺炎等等。我就是受害者。对了肠道疾病。。。。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1741838, encodeId=13431e418383e, content=<a href='/topic/show?id=653113e0852' target=_blank style='color:#2F92EE;'>#Pancreas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13708, encryptionId=653113e0852, topicName=Pancreas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a00434942797, createdName=ms6747015003810650, createdTime=Sun Jan 17 19:07:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65306, encodeId=021b65306fb, content=牙周病, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b6041668753, createdName=源源, createdTime=Wed Feb 24 01:55:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65307, encodeId=62086530e4c, content=不能收藏?, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b6041668753, createdName=源源, createdTime=Wed Feb 24 01:55:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55510, encodeId=0361555107b, content=牙有病引发全身病!高血压。糖尿病。胃病。姨腺炎等等。我就是受害者。对了肠道疾病。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Sun Jan 10 12:38:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47083, encodeId=dac84e08381, content=科普, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Dec 22 17:08:00 CST 2015, time=2015-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45488, encodeId=6d284548897, content=的确是真的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Thu Dec 10 16:34:00 CST 2015, time=2015-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41026, encodeId=d9824102628, content=应该大力科普!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25101619573, createdName=zhixue, createdTime=Sun Oct 25 11:46:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40078, encodeId=d773400e8e3, content=的确如此!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Wed Oct 21 18:21:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282233, encodeId=6eb2128223324, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Wed Oct 21 11:07:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450431, encodeId=0e2614504314b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Oct 21 11:07:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
    2015-12-22 xiaotaiyang1

    科普

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1741838, encodeId=13431e418383e, content=<a href='/topic/show?id=653113e0852' target=_blank style='color:#2F92EE;'>#Pancreas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13708, encryptionId=653113e0852, topicName=Pancreas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a00434942797, createdName=ms6747015003810650, createdTime=Sun Jan 17 19:07:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65306, encodeId=021b65306fb, content=牙周病, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b6041668753, createdName=源源, createdTime=Wed Feb 24 01:55:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65307, encodeId=62086530e4c, content=不能收藏?, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b6041668753, createdName=源源, createdTime=Wed Feb 24 01:55:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55510, encodeId=0361555107b, content=牙有病引发全身病!高血压。糖尿病。胃病。姨腺炎等等。我就是受害者。对了肠道疾病。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Sun Jan 10 12:38:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47083, encodeId=dac84e08381, content=科普, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Dec 22 17:08:00 CST 2015, time=2015-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45488, encodeId=6d284548897, content=的确是真的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Thu Dec 10 16:34:00 CST 2015, time=2015-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41026, encodeId=d9824102628, content=应该大力科普!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25101619573, createdName=zhixue, createdTime=Sun Oct 25 11:46:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40078, encodeId=d773400e8e3, content=的确如此!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Wed Oct 21 18:21:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282233, encodeId=6eb2128223324, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Wed Oct 21 11:07:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450431, encodeId=0e2614504314b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Oct 21 11:07:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
    2015-12-10 1dd82894m82(暂无匿称)

    的确是真的!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1741838, encodeId=13431e418383e, content=<a href='/topic/show?id=653113e0852' target=_blank style='color:#2F92EE;'>#Pancreas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13708, encryptionId=653113e0852, topicName=Pancreas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a00434942797, createdName=ms6747015003810650, createdTime=Sun Jan 17 19:07:00 CST 2016, time=2016-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65306, encodeId=021b65306fb, content=牙周病, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b6041668753, createdName=源源, createdTime=Wed Feb 24 01:55:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65307, encodeId=62086530e4c, content=不能收藏?, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b6041668753, createdName=源源, createdTime=Wed Feb 24 01:55:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55510, encodeId=0361555107b, content=牙有病引发全身病!高血压。糖尿病。胃病。姨腺炎等等。我就是受害者。对了肠道疾病。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Sun Jan 10 12:38:00 CST 2016, time=2016-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47083, encodeId=dac84e08381, content=科普, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Tue Dec 22 17:08:00 CST 2015, time=2015-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45488, encodeId=6d284548897, content=的确是真的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Thu Dec 10 16:34:00 CST 2015, time=2015-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41026, encodeId=d9824102628, content=应该大力科普!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25101619573, createdName=zhixue, createdTime=Sun Oct 25 11:46:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40078, encodeId=d773400e8e3, content=的确如此!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acd01628312, createdName=1dd82894m82(暂无匿称), createdTime=Wed Oct 21 18:21:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282233, encodeId=6eb2128223324, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Wed Oct 21 11:07:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450431, encodeId=0e2614504314b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Oct 21 11:07:00 CST 2015, time=2015-10-21, status=1, ipAttribution=)]
    2015-10-25 zhixue

    应该大力科普!

    0

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    2015-10-21 1dd82894m82(暂无匿称)

    的确如此!

    0

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