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一图读懂:肿瘤标志物全面解析

2019-06-28 不详 网络

肿瘤标志物图解 以下盘点了最常见的肿瘤标志物,包括甲胎蛋白、癌胚抗原、癌抗原125等 1、甲胎蛋白(AFP) AFP是诊断原发性肝癌的最佳标志物,诊断阳性率为60%~70%。血清AFP>400μg/L持续4周,或200~400μg/L持续8周者,结合影像检查,可作出原发性肝癌的诊断。 2、癌胚抗原(CEA) 癌胚抗原是从胎儿及结肠癌组织中发现的一种糖蛋白胚

肿瘤标志物图解


以下盘点了最常见的肿瘤标志物,包括甲胎蛋白、癌胚抗原、癌抗原125等


1、甲胎蛋白(AFP)

AFP是诊断原发性肝癌的最佳标志物,诊断阳性率为60%~70%。血清AFP>400μg/L持续4周,或200~400μg/L持续8周者,结合影像检查,可作出原发性肝癌的诊断。

2、癌胚抗原(CEA)

癌胚抗原是从胎儿及结肠癌组织中发现的一种糖蛋白胚胎抗原,属于广谱性肿瘤标志物。CEA在恶性肿瘤中的阳性率依次为结肠癌(70%)、癌(60%)、胰腺癌(55%)、肺癌(50%)、乳腺癌(40%)、卵巢癌(30%)、子宫癌(30%)。

3、癌抗原125(CA125)

CA125存在于上皮卵巢癌组织和病人血清中,是研究最多的卵巢癌标记物,在早期筛查、诊断、治疗及预后的应用研究均有重要意义。CA125对卵巢上皮癌的敏感性可达约70%。

4、癌抗原15-3(CA15-3)

CA15-3可作为乳腺癌辅助诊断,术后随访和转移复发的指标。对早期乳腺癌的敏感性较低(60%),晚期的敏感性为80%,转移性乳腺癌的阳性率较高(80%)。

5、糖类抗原19-9(CA19-9)

CA19-9是一种与肠道癌相关的糖类抗原,通常分布于正常胎儿胰腺、胆囊、肝、肠及正常成年人胰腺、胆管上皮等处。检测患者血清CA19-9可作为胰腺癌、胆囊癌等恶性肿瘤的辅助诊断指标,对监测病情变化和复发有很大意义。

6、癌抗原50(CA50)

CA50是胰腺和结、直肠癌的标志物,是最常用的糖类抗原肿瘤标志物,它又是一种普遍的肿瘤标志相关抗原,而不是特指某个器官的肿瘤标志物。

7、糖类抗原242(CA242)

CA242是与胰腺癌、胃癌、大肠癌相关的糖脂类抗原。血清CA242用于胰腺癌,大肠癌的辅助诊断,有较好的敏感性(80%)和特异性(90%)。肺癌,肝癌,卵巢癌患者的血清CA242含量可见升高。

8、胃癌相关抗原(CA72-4)

CA72-4是目前诊断胃癌的最佳肿瘤标志物之一,对胃癌具有较高的特异性,其敏感性可达28%-80%,若与CA19-9及CEA联合检测可以监测70%以上的胃癌。

9、铁蛋白(SF)

铁蛋白升高可见于下列肿瘤:急性白血病、霍奇金病、肺癌、结肠癌、肝癌和前列腺癌。检测铁蛋白对肝脏转移性肿瘤有诊断价值,76%的肝转移病人铁蛋白含量高于400μg/L,当肝癌时,AFP测定值较低的情况下,可用铁蛋白测定值补充,以提高诊断率。

10、前列腺特异抗原(PSA)

PSA是由人前列腺上皮细胞合成并分泌至精浆中的一种糖蛋白,PSA主要存在于前列腺组织中,女性体内不存在,正常男性血清中PSA的含量很低,血清参考值<4μg/L;PSA具有器官特异性,但不具有肿瘤特异性。诊断前列腺癌的阳性率为80%。良性前列腺疾病也可见血清PSA水平不同程度升高。

11、前列腺酸性磷酸酶(PAP)

前列腺癌血清PAP升高,是前列腺癌诊断、分期、疗效观察及预后的重要指标。前列腺炎和前列腺增生PAP也有一定程度的增高。

12、β2微球蛋白(β2-MG)

临床上多用于诊断淋巴增殖性疾病,如白血病、淋巴瘤及多发性骨髓瘤。其水平与肿瘤细胞数量、生长速率、预后及疾病活动性有关。此外,根据此水平还可用于骨髓瘤患者分期。

13、神经元特异性烯醇化酶(NSE)

NSE为烯醇化酶的一种同工酶。NSE是小细胞肺癌(SCLC)的肿瘤标志物,诊断阳性率为91%。有助于小细胞肺癌和非小细胞肺癌(NSCLC)的鉴别诊断。对小细胞肺癌的疗效观察和复发监测也有重要价值。神经母细胞瘤,神经内分泌细胞瘤的血清NSE浓度可明显升高。

14、细胞角蛋白19(Cyfra21-1)

Cyfra21-1是细胞角蛋白-19的可溶性片段。Cyfra21-1是非小细胞肺癌,特别是肺鳞癌的首选标志物。与CEA和NSE联合检测对肺癌的鉴别诊断,病情监测有重要价值。

15、鳞状细胞癌抗原(SCCA)

鳞状细胞癌抗原(SCCA)是从宫颈鳞状上皮细胞癌组织提取的肿瘤相关抗原TA-4,正常人血清含量极微<2.5μg/L。SCCA是鳞癌的肿瘤标志物,适用于宫颈癌、肺鳞癌、食管癌、头颈部癌,膀胱癌的辅助诊断,治疗观察和复发监测。

16、核基质蛋白-22(NMP-22)

膀胱癌时大量肿瘤细胞凋亡并将NMP22释放入尿,尿中NMP22可增高25倍。以10kU/mL为临界值,对膀胱癌诊断的敏感度。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=925414, encodeId=249a92541423, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/u2N3lFzvSjicl5Dapj52quzicvDZI9ZXHSbnQsBJEkGvrV6LibibxBUhHSqH5ibTTBvrGxnOEib88p6iabJ2iaL3RpN7Yg/132, createdBy=67d42417933, createdName=中果, createdTime=Fri Feb 19 09:19:40 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906194, encodeId=0f4b906194a6, content=ca125浆膜受累升高很常见, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88a15442706, createdName=ms8000001267103871, createdTime=Tue Dec 08 23:02:23 CST 2020, time=2020-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897830, encodeId=aa3489e83022, content=肺癌 尤其女性,CA125高很常见。, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e7572458878, createdName=12412355m93暂无昵称, createdTime=Sun Nov 08 21:39:19 CST 2020, time=2020-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883076, encodeId=c09e8830e646, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55955411286, createdName=ms6000001009939572, createdTime=Sun Sep 06 11:38:52 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881013, encodeId=1e9d881013f2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3c5410793, createdName=蓝莓, createdTime=Sun Aug 30 19:12:19 CST 2020, time=2020-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841401, encodeId=0f071841401c7, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed May 06 02:51:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1672927, encodeId=277616e2927db, content=<a href='/topic/show?id=b79b910345c' target=_blank style='color:#2F92EE;'>#解析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91034, encryptionId=b79b910345c, topicName=解析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f42d26916490, createdName=hongbochen, createdTime=Sat Sep 28 15:51:00 CST 2019, time=2019-09-28, status=1, ipAttribution=)]
    2021-02-19 中果

    学习

    0

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    2020-12-08 ms8000001267103871

    ca125浆膜受累升高很常见

    0

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    2020-11-08 12412355m93暂无昵称

    肺癌 尤其女性,CA125高很常见。

    0

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    2020-09-06 ms6000001009939572

    mark

    0

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    2020-08-30 蓝莓

    学习

    0

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    2019-09-28 hongbochen

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