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血栓性血小板减少性紫癜诊断与治疗中国专家共识(2012年版)

2012-11-01 中华血液学杂志,2012,11,33(11):983-984

血栓

中文标题：

血栓性血小板减少性紫癜诊断与治疗中国专家共识(2012年版)

发布机构：

发布日期：

2012-11-01

简要介绍：

血栓性血小板减少性紫癜(TTP)为一组微血管血栓出血综合征，其主要临床特征包括微血管病性溶血性贫血、血小板减少、神经精神症状、发热和肾脏受累等。TTP的主要发病机制涉及血管性血友病因子(VWF)裂解蛋白酶(ADAMTSl3)活性缺乏、血管内皮细胞VWF异常释放、血小板异常活化等方面。TTP分为遗传性和获得性两种，后者根据有无原发病分为特发性和继发性。遗传性TTP系ADAMTSl3基因突变导致酶活性降低或缺乏所致，常在感染、应激或妊娠等诱发因素作用下发病。特发性TTP多因患者体内存在抗ADAMTSl3自身抗体(抑制物)，导致ADAMTSl3活性降低或缺乏，是主要的临床类型。继发性TTP系因感染、药物、肿瘤、自身免疫性疾病、造血干细胞移植等因素引发，发病机制复杂，预后不佳。

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    2021-12-29 146cdb0fm09暂无昵称

    非常好

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    2021-08-21 14860c3dm72暂无昵称

    #梅斯医学科研互助群#学习

    0

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    2021-08-21 14860c3dm72暂无昵称

    #心血管#学习

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1085345, encodeId=cd341085345f2, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56545167768, createdName=146cdb0fm09暂无昵称, createdTime=Wed Dec 29 09:16:02 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009929, encodeId=3a5010099297e, content=<a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fb05290382, createdName=14860c3dm72暂无昵称, createdTime=Sat Aug 21 08:43:34 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009928, encodeId=9133100992870, content=<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fb05290382, createdName=14860c3dm72暂无昵称, createdTime=Sat Aug 21 08:43:28 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009927, encodeId=8e6e100992e75, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fb05290382, createdName=14860c3dm72暂无昵称, createdTime=Sat Aug 21 08:43:18 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369892, encodeId=f2c6369892dc, content=不能下载？, beContent=null, objectType=guider, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJwvKJWbmnoSkGUyfd22qTlsc5Ffl3QMYjeylBfxu8bOLMBEibNcMd0mg6IT6EtQrVtxnkAM1p6kPQ/132, createdBy=b0a52326441, createdName=枫林5230, createdTime=Thu Jul 18 14:57:58 CST 2019, time=2019-07-18, status=1, ipAttribution=)]
    2021-08-21 14860c3dm72暂无昵称

    #学习#学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1085345, encodeId=cd341085345f2, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56545167768, createdName=146cdb0fm09暂无昵称, createdTime=Wed Dec 29 09:16:02 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009929, encodeId=3a5010099297e, content=<a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a>学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fb05290382, createdName=14860c3dm72暂无昵称, createdTime=Sat Aug 21 08:43:34 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009928, encodeId=9133100992870, content=<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fb05290382, createdName=14860c3dm72暂无昵称, createdTime=Sat Aug 21 08:43:28 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1009927, encodeId=8e6e100992e75, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fb05290382, createdName=14860c3dm72暂无昵称, createdTime=Sat Aug 21 08:43:18 CST 2021, time=2021-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369892, encodeId=f2c6369892dc, content=不能下载？, beContent=null, objectType=guider, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJwvKJWbmnoSkGUyfd22qTlsc5Ffl3QMYjeylBfxu8bOLMBEibNcMd0mg6IT6EtQrVtxnkAM1p6kPQ/132, createdBy=b0a52326441, createdName=枫林5230, createdTime=Thu Jul 18 14:57:58 CST 2019, time=2019-07-18, status=1, ipAttribution=)]
    2019-07-18 枫林5230

    不能下载？

    0

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