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2021 ESC 心脏细胞电生理学工作组立场文件：心脏电生理学研究实验模型的相关性、机会和局限性

2021-07-27 欧洲心脏病学会 Europace . 2021 Jul 27;

电生理学

心律失常是导致死亡和残疾的一个主要原因。大量的实验性细胞和动物模型已经被开发出来以研究心律失常疾病。这些模型提供了对潜在心律失常机制的重要见解和对其治疗管理的转化选择。这份来自ESC心脏细胞电生理工作

中文标题：

2021 ESC 心脏细胞电生理学工作组立场文件：心脏电生理学研究实验模型的相关性、机会和局限性

英文标题：

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research

发布机构：

欧洲心脏病学会

发布日期：

2021-07-27

简要介绍：

心律失常是导致死亡和残疾的一个主要原因。大量的实验性细胞和动物模型已经被开发出来以研究心律失常疾病。这些模型提供了对潜在心律失常机制的重要见解和对其治疗管理的转化选择。这份来自ESC心脏细胞电生理工作组的立场文件概述了（i）目前可用的体外、体内和体内电生理研究方法，（ii）最常用的心律失常实验（细胞和动物）模型，包括相关物种差异，（iii）人类心脏组织的使用。诱导多能干细胞(hiPSC)衍生的和硅学模型来研究心律失常，以及(iv) 这些细胞和动物模型的可用性、相关性、局限性和机会，以再现特定的获得性和遗传性心律失常疾病，包括心房颤动、心力衰竭、心肌病、心肌炎、窦房结、传导障碍和通道病。通过促进对这些模型及其局限性的了解，本立场文件旨在提高心脏电生理学基础研究的质量，最终目的是促进心律失常机制和治疗方法的基础电生理学研究结果的临床转化和应用。

 

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    2021-12-15 ms3000000734162967

    学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1080144, encodeId=f001108014400, content=学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cd96166904, createdName=ms3000000734162967, createdTime=Wed Dec 15 00:47:29 CST 2021, time=2021-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1080143, encodeId=ee5810801430a, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cd96166904, createdName=ms3000000734162967, createdTime=Wed Dec 15 00:43:52 CST 2021, time=2021-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1080023, encodeId=7ee3108002348, content=学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Tue Dec 14 17:39:37 CST 2021, time=2021-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1080015, encodeId=20141080015e3, content=很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200803/cf3e63470dcf41a58117b7609eb258af/f137b3eb57b44c109b25f5a631307450.jpg, createdBy=e4c95408509, createdName=中南小哥, createdTime=Tue Dec 14 17:15:14 CST 2021, time=2021-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055939, encodeId=95051055939ac, content=感谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=989a5607928, createdName=H8888888, createdTime=Wed Sep 29 08:56:42 CST 2021, time=2021-09-29, status=1, ipAttribution=)]
    2021-12-15 ms3000000734162967

    学习了

    0

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    2021-12-14 ms5000000518166734

    学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习

    0

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    2021-12-14 中南小哥

    很好

    0

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    2021-09-29 H8888888

    感谢分享

    0

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