2016 AACE/ACE立场声明：SGLT-2抑制剂和糖尿病酮症酸中毒的关系

2016-04-27 美国临床内分泌医师学会 Endocr Pract. 2016 Jun 1.

2016年4月，美国临床内分泌医师学会(AACE)以及美国内分泌学院(ACE)共同发布了关于SGLT-2抑制剂和糖尿病酮症酸中毒关系的立场声明，主要内容涉及SGLT-2抑制剂应用相关的糖尿病酸中毒。Review of available data on the prevalence of SGLT-2-associated DKA as well as the impact of&nbs

中文标题：

英文标题：

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS.

发布机构：

美国临床内分泌医师学会

发布日期：

2016-04-27

简要介绍：

2016年4月，美国临床内分泌医师学会(AACE)以及美国内分泌学院(ACE)共同发布了关于SGLT-2抑制剂和糖尿病酮症酸中毒关系的立场声明，主要内容涉及SGLT-2抑制剂应用相关的糖尿病酸中毒。

Review of available data on the prevalence of SGLT-2-associated DKA as well as the impact of SGLT-2 inhibitors on human metabolism suggests that DKA occurs infrequently and that the risk-benefit ratio overwhelmingly favors continued use of SGLT-2 inhibitors with no changes in current recommendations. However, DKA diagnosis may be missed or delayed due to atypical presentation involving lower-than-anticipated glucose levels or other misleading laboratory values. This presentation has been seen with SGLT-2 inhibitors but has also been observed for decades before the introduction of these agents (9). Gaps in understanding call for more studies of the mechanisms behind the metabolic effect of SGLT-2 inhibitors as well as more healthcare professional education focused on the proper diagnosis and treatment of DKA.

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