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与夜间遗尿症相关的遗传位点的鉴定:全基因组关联研究

2021-01-14 Lancet Child Adolesc Health

在全球范围内,10%-16%的7岁儿童患有夜间遗尿症。夜间遗尿是高度可遗传的,但其遗传决定因素仍然未知。我们旨在鉴定与夜间遗尿症相关的遗传变异,

中文标题:

与夜间遗尿症相关的遗传位点的鉴定:全基因组关联研究

英文标题:

Identification of genetic loci associated with nocturnal enuresis: a genome-wide association study

发布机构:

发布日期:

2021-01-14

简要介绍:

在全球范围内,10%-16%的7岁儿童患有夜间遗尿症。夜间遗尿是高度可遗传的,但其遗传决定因素仍然未知。我们旨在鉴定与夜间遗尿症相关的遗传变异,
并探索其遗传结构和潜在生物学。这项研究表明,常见的遗传变异在很大程度上有助于夜间遗尿症,它确定了在睡眠,尿液产生和膀胱功能中起作用的潜在夜间遗尿症风险基因。鉴于可用的治疗靶向的机制。任何鉴定的基因及其功能基因网络都是潜在药物靶标。

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