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2022 CPIC指南：CYP2C19基因型与氯吡格雷治疗（更新版）

2022-01-16 临床药物基因组学实施联盟 Clin Pharmacol Ther

氯吡格雷CYP2C19基因型

2022年1月，临床药物基因组学实施联盟(CPIC)更新发布了CYP2C19基因型与氯吡格雷治疗指南。CYP2C19催化抗血小板前药氯吡格雷的生物活性，CYP2C19基因型影响氯吡格雷活性代谢物的形成

中文标题：

2022 CPIC指南：CYP2C19基因型与氯吡格雷治疗（更新版）

英文标题：

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update

发布机构：

临床药物基因组学实施联盟

发布日期：

2022-01-16

简要介绍：

2022年1月，临床药物基因组学实施联盟(CPIC)更新发布了CYP2C19基因型与氯吡格雷治疗指南。CYP2C19催化抗血小板前药氯吡格雷的生物活性，CYP2C19基因型影响氯吡格雷活性代谢物的形成。接受氯吡格雷治疗的CYP2C19中间代谢和代谢不良者的血小板控制率降低，主要不良心脑血管事件风险增加。本文是对2013年版CYP2C19基因型与氯吡格雷治疗指南的更新。

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