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二甲双胍调控H19介导SLC7A11蛋白UFMylation修饰促进乳腺癌细胞铁死亡的机制研究

负责人：周济春

依托单位：浙江大学

批准年份：2019

前往基金查询
项目简介
项目名称
二甲双胍调控H19介导SLC7A11蛋白UFMylation修饰促进乳腺癌细胞铁死亡的机制研究
项目批准号
81972453
学科分类
H1622 医学科学
资助类型
面上项目
负责人
周济春
依托单位
浙江大学
批准年份
2019
起止时间
202001-202312
批准金额
55.00万元
摘要
暂无数据
相关基金
靶向ULK1小分子激动剂诱导三阴性乳腺癌自噬性细胞死亡和凋亡的机制研究
 二甲双胍诱导的乳腺干细胞调控在erbB2+乳腺癌预防中的作用与机理
 调控与干预ERα和p53状态对乳腺癌细胞凋亡影响的研究
 维甲酸β受体介导乳腺癌细胞凋亡的分子机制
 基于铁死亡增强的三阴性乳腺癌治疗性疫苗的设计与应用研究
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=886514, encodeId=5482886514b9, content=有关XX化，也有一堆新东西，如最早的<a href='/topic/show?id=bef8e3852a3' target=_blank style='color:#2F92EE;'>#磷酸化#</a><a href='/topic/show?id=7d0764900ce' target=_blank style='color:#2F92EE;'>#泛素化#</a>，后来是<a href='/topic/show?id=ddd623463b1' target=_blank style='color:#2F92EE;'>#乙酰化#</a>和<a href='/topic/show?id=ec6569e7806' target=_blank style='color:#2F92EE;'>#甲基化#</a>，进一步出现了<a href='/topic/show?id=e2bfe35318a' target=_blank style='color:#2F92EE;'>#硝基化#</a>，<a href='/topic/show?id=7a396261000' target=_blank style='color:#2F92EE;'>#棕榈酰化#</a>，<a href='/topic/show?id=2779168993a' target=_blank style='color:#2F92EE;'>#SUMO化#</a>，现在又出现<a href='/topic/show?id=d6cb10392563' target=_blank style='color:#2F92EE;'>#UFM化#</a>，不断有新名词，只是这些新名词背后的价值是什么，仅仅是发几篇CNS文章？不过<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>够神奇的，与啥都能扯关系，包括降糖，抗癌，促进自噬，增加肿瘤免疫作用等 , beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=251, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73852, encryptionId=bef8e3852a3, topicName=磷酸化), TopicDto(id=64900, encryptionId=7d0764900ce, topicName=泛素化), TopicDto(id=23463, encryptionId=ddd623463b1, topicName=乙酰化), TopicDto(id=69778, encryptionId=ec6569e7806, topicName=甲基化), TopicDto(id=73531, encryptionId=e2bfe35318a, topicName=硝基化), TopicDto(id=62610, encryptionId=7a396261000, topicName=棕榈酰化), TopicDto(id=16899, encryptionId=2779168993a, topicName=SUMO化), TopicDto(id=103925, encryptionId=d6cb10392563, topicName=UFM化), TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:18:17 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886510, encodeId=07ad88651022, content= <a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a></a>是这几年细胞死亡的最火的研究形式了。从最早的<a href='/topic/show?id=992ee7859a4' target=_blank style='color:#2F92EE;'>#细胞坏死#</a>，到<a href='/topic/show?id=420a31219ba' target=_blank style='color:#2F92EE;'>#凋亡#</a>，进一步发现<a href='/topic/show?id=1c7a103923a4' target=_blank style='color:#2F92EE;'>#胀亡#</a>，<a href='/topic/show?id=6f65e52572c' target=_blank style='color:#2F92EE;'>#程序性坏死#</a>，<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>等细胞的存活与死亡形式。最近几年火了<a href='/topic/show?id=1419103924ce' target=_blank style='color:#2F92EE;'>#焦亡#</a>和<a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a></a>，新概念不断发生，但是这些基础研究离临床应用还很远。如果要申请基金，就必需要跟踪这些最新进展才可以, beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=285, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96543, encryptionId=afa5965438d, topicName=铁死亡), TopicDto(id=77859, encryptionId=992ee7859a4, topicName=细胞坏死), TopicDto(id=31219, encryptionId=420a31219ba, topicName=凋亡), TopicDto(id=103923, encryptionId=1c7a103923a4, topicName=胀亡), TopicDto(id=75257, encryptionId=6f65e52572c, topicName=程序性坏死), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬), TopicDto(id=103924, encryptionId=1419103924ce, topicName=焦亡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:13:44 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886509, encodeId=0756886509d3, content=<a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a>是这几年细胞死亡的最火的研究形式了。从最早的<a href='/topic/show?id=992ee7859a4' target=_blank style='color:#2F92EE;'>#细胞坏死#</a>，到<a href='/topic/show?id=420a31219ba' target=_blank style='color:#2F92EE;'>#凋亡#</a>, beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=269, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96543, encryptionId=afa5965438d, topicName=铁死亡), TopicDto(id=77859, encryptionId=992ee7859a4, topicName=细胞坏死), TopicDto(id=31219, encryptionId=420a31219ba, topicName=凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:12:25 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 lovetcm

    有关XX化，也有一堆新东西，如最早的#磷酸化##泛素化#，后来是#乙酰化#和#甲基化#，进一步出现了#硝基化#，#棕榈酰化#，#SUMO化#，现在又出现#UFM化#，不断有新名词，只是这些新名词背后的价值是什么，仅仅是发几篇CNS文章？不过#二甲双胍#够神奇的，与啥都能扯关系，包括降糖，抗癌，促进自噬，增加肿瘤免疫作用等

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=886514, encodeId=5482886514b9, content=有关XX化，也有一堆新东西，如最早的<a href='/topic/show?id=bef8e3852a3' target=_blank style='color:#2F92EE;'>#磷酸化#</a><a href='/topic/show?id=7d0764900ce' target=_blank style='color:#2F92EE;'>#泛素化#</a>，后来是<a href='/topic/show?id=ddd623463b1' target=_blank style='color:#2F92EE;'>#乙酰化#</a>和<a href='/topic/show?id=ec6569e7806' target=_blank style='color:#2F92EE;'>#甲基化#</a>，进一步出现了<a href='/topic/show?id=e2bfe35318a' target=_blank style='color:#2F92EE;'>#硝基化#</a>，<a href='/topic/show?id=7a396261000' target=_blank style='color:#2F92EE;'>#棕榈酰化#</a>，<a href='/topic/show?id=2779168993a' target=_blank style='color:#2F92EE;'>#SUMO化#</a>，现在又出现<a href='/topic/show?id=d6cb10392563' target=_blank style='color:#2F92EE;'>#UFM化#</a>，不断有新名词，只是这些新名词背后的价值是什么，仅仅是发几篇CNS文章？不过<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>够神奇的，与啥都能扯关系，包括降糖，抗癌，促进自噬，增加肿瘤免疫作用等 , beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=251, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73852, encryptionId=bef8e3852a3, topicName=磷酸化), TopicDto(id=64900, encryptionId=7d0764900ce, topicName=泛素化), TopicDto(id=23463, encryptionId=ddd623463b1, topicName=乙酰化), TopicDto(id=69778, encryptionId=ec6569e7806, topicName=甲基化), TopicDto(id=73531, encryptionId=e2bfe35318a, topicName=硝基化), TopicDto(id=62610, encryptionId=7a396261000, topicName=棕榈酰化), TopicDto(id=16899, encryptionId=2779168993a, topicName=SUMO化), TopicDto(id=103925, encryptionId=d6cb10392563, topicName=UFM化), TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:18:17 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886510, encodeId=07ad88651022, content= <a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a></a>是这几年细胞死亡的最火的研究形式了。从最早的<a href='/topic/show?id=992ee7859a4' target=_blank style='color:#2F92EE;'>#细胞坏死#</a>，到<a href='/topic/show?id=420a31219ba' target=_blank style='color:#2F92EE;'>#凋亡#</a>，进一步发现<a href='/topic/show?id=1c7a103923a4' target=_blank style='color:#2F92EE;'>#胀亡#</a>，<a href='/topic/show?id=6f65e52572c' target=_blank style='color:#2F92EE;'>#程序性坏死#</a>，<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>等细胞的存活与死亡形式。最近几年火了<a href='/topic/show?id=1419103924ce' target=_blank style='color:#2F92EE;'>#焦亡#</a>和<a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a></a>，新概念不断发生，但是这些基础研究离临床应用还很远。如果要申请基金，就必需要跟踪这些最新进展才可以, beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=285, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96543, encryptionId=afa5965438d, topicName=铁死亡), TopicDto(id=77859, encryptionId=992ee7859a4, topicName=细胞坏死), TopicDto(id=31219, encryptionId=420a31219ba, topicName=凋亡), TopicDto(id=103923, encryptionId=1c7a103923a4, topicName=胀亡), TopicDto(id=75257, encryptionId=6f65e52572c, topicName=程序性坏死), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬), TopicDto(id=103924, encryptionId=1419103924ce, topicName=焦亡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:13:44 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886509, encodeId=0756886509d3, content=<a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a>是这几年细胞死亡的最火的研究形式了。从最早的<a href='/topic/show?id=992ee7859a4' target=_blank style='color:#2F92EE;'>#细胞坏死#</a>，到<a href='/topic/show?id=420a31219ba' target=_blank style='color:#2F92EE;'>#凋亡#</a>, beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=269, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96543, encryptionId=afa5965438d, topicName=铁死亡), TopicDto(id=77859, encryptionId=992ee7859a4, topicName=细胞坏死), TopicDto(id=31219, encryptionId=420a31219ba, topicName=凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:12:25 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 lovetcm

    #铁死亡#是这几年细胞死亡的最火的研究形式了。从最早的#细胞坏死#，到#凋亡#，进一步发现#胀亡#，#程序性坏死#，#自噬#等细胞的存活与死亡形式。最近几年火了#焦亡#和#铁死亡#，新概念不断发生，但是这些基础研究离临床应用还很远。如果要申请基金，就必需要跟踪这些最新进展才可以

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=886514, encodeId=5482886514b9, content=有关XX化，也有一堆新东西，如最早的<a href='/topic/show?id=bef8e3852a3' target=_blank style='color:#2F92EE;'>#磷酸化#</a><a href='/topic/show?id=7d0764900ce' target=_blank style='color:#2F92EE;'>#泛素化#</a>，后来是<a href='/topic/show?id=ddd623463b1' target=_blank style='color:#2F92EE;'>#乙酰化#</a>和<a href='/topic/show?id=ec6569e7806' target=_blank style='color:#2F92EE;'>#甲基化#</a>，进一步出现了<a href='/topic/show?id=e2bfe35318a' target=_blank style='color:#2F92EE;'>#硝基化#</a>，<a href='/topic/show?id=7a396261000' target=_blank style='color:#2F92EE;'>#棕榈酰化#</a>，<a href='/topic/show?id=2779168993a' target=_blank style='color:#2F92EE;'>#SUMO化#</a>，现在又出现<a href='/topic/show?id=d6cb10392563' target=_blank style='color:#2F92EE;'>#UFM化#</a>，不断有新名词，只是这些新名词背后的价值是什么，仅仅是发几篇CNS文章？不过<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>够神奇的，与啥都能扯关系，包括降糖，抗癌，促进自噬，增加肿瘤免疫作用等 , beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=251, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73852, encryptionId=bef8e3852a3, topicName=磷酸化), TopicDto(id=64900, encryptionId=7d0764900ce, topicName=泛素化), TopicDto(id=23463, encryptionId=ddd623463b1, topicName=乙酰化), TopicDto(id=69778, encryptionId=ec6569e7806, topicName=甲基化), TopicDto(id=73531, encryptionId=e2bfe35318a, topicName=硝基化), TopicDto(id=62610, encryptionId=7a396261000, topicName=棕榈酰化), TopicDto(id=16899, encryptionId=2779168993a, topicName=SUMO化), TopicDto(id=103925, encryptionId=d6cb10392563, topicName=UFM化), TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:18:17 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886510, encodeId=07ad88651022, content= <a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a></a>是这几年细胞死亡的最火的研究形式了。从最早的<a href='/topic/show?id=992ee7859a4' target=_blank style='color:#2F92EE;'>#细胞坏死#</a>，到<a href='/topic/show?id=420a31219ba' target=_blank style='color:#2F92EE;'>#凋亡#</a>，进一步发现<a href='/topic/show?id=1c7a103923a4' target=_blank style='color:#2F92EE;'>#胀亡#</a>，<a href='/topic/show?id=6f65e52572c' target=_blank style='color:#2F92EE;'>#程序性坏死#</a>，<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>等细胞的存活与死亡形式。最近几年火了<a href='/topic/show?id=1419103924ce' target=_blank style='color:#2F92EE;'>#焦亡#</a>和<a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a></a>，新概念不断发生，但是这些基础研究离临床应用还很远。如果要申请基金，就必需要跟踪这些最新进展才可以, beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=285, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96543, encryptionId=afa5965438d, topicName=铁死亡), TopicDto(id=77859, encryptionId=992ee7859a4, topicName=细胞坏死), TopicDto(id=31219, encryptionId=420a31219ba, topicName=凋亡), TopicDto(id=103923, encryptionId=1c7a103923a4, topicName=胀亡), TopicDto(id=75257, encryptionId=6f65e52572c, topicName=程序性坏死), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬), TopicDto(id=103924, encryptionId=1419103924ce, topicName=焦亡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:13:44 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886509, encodeId=0756886509d3, content=<a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a>是这几年细胞死亡的最火的研究形式了。从最早的<a href='/topic/show?id=992ee7859a4' target=_blank style='color:#2F92EE;'>#细胞坏死#</a>，到<a href='/topic/show?id=420a31219ba' target=_blank style='color:#2F92EE;'>#凋亡#</a>, beContent=null, objectType=nsfc, channel=null, level=null, likeNumber=269, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96543, encryptionId=afa5965438d, topicName=铁死亡), TopicDto(id=77859, encryptionId=992ee7859a4, topicName=细胞坏死), TopicDto(id=31219, encryptionId=420a31219ba, topicName=凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 22:12:25 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 lovetcm

    #铁死亡#是这几年细胞死亡的最火的研究形式了。从最早的#细胞坏死#，到#凋亡#

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