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A novel mouse model for an inducible gene modification in the renal thick ascending limb

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 324 (5)

The thick ascending limb (TAL) is critical for renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bume......

Evidence that methylglyoxal and receptor for advanced glycation end products are implicated in bladder dysfunction of obese diabetic ob/ob mice

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (4)

Glycolytic overload in diabetes causes large accumulation of the highly reactive dicarbonyl compound methylglyoxal (MGO) and overproduction of advance......

Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (5)

Hypoxia and oxidative stress are considered to be underlying factors in the deterioration of renal function and pathogenesis in acute kidney injury (A......

Assessment of renal sympathetic control using invasive pressure and flow velocity measurements in humans

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (3)

Renal sympathetic innervation is important in the control of renal and systemic hemodynamics and is a target for pharmacological and catheter-based th......

Salt-sensitive trait of normotensive individuals is associated with altered autonomous cardiac regulation: a randomized controlled intervention study

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (6)

Blood pressure (BP) responses to sodium intake show great variation, discriminating salt-sensitive (SS) from salt-resistant (SR) individuals. The path......

Hi, how can i help you?: embracing artificial intelligence in kidney research

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (4)

In recent years, biology and precision medicine have benefited from major advancements in generating large-scale molecular and biomedical datasets and......

Postoperative acute kidney injury after volatile or intravenous anesthesia: a meta-analysis

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 324 (4)

Postoperative acute kidney injury (AKI) is a common complication after surgery. The pathophysiology of postoperative AKI is complex. One potentially i......

The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (5)

Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. This increased risk cannot be fully explained by tradition......

Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (5)

Hypoxia and oxidative stress are considered to be underlying factors in the deterioration of renal function and pathogenesis in acute kidney injury (A......

Role of the SLC22A17/lipocalin-2 receptor in renal endocytosis of proteins/metalloproteins: a focus on iron- and cadmium-binding proteins

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (5)

The transmembrane protein SLC22A17 [or the neutrophil gelatinase-associated lipocalin/lipocalin-2 (LCN2)/24p3 receptor] is an atypical member of the S......

Influence of administration time and sex on natriuretic, diuretic, and kaliuretic effects of diuretics

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 324 (3)

Sex differences in renal function and blood pressure have been widely described across many species. Blood pressure dips dur-ing sleep and peaks in th......

Abnormal glomerular basement membrane maturation impairs mesangial cell differentiation during murine postnatal nephrogenesis

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 324 (1)

Although mesangial cell-glomerular basement membrane (GBM) connections play a key role in maintaining the glomerular capil-lary loop structure, inform......

Neuropilin 1 promotes unilateral ureteral obstruction-induced renal fibrosis via RACK1 in renal tubular epithelial cells

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (6)

Neuropilin 1 (NRP1) is a single-channel transmembrane glycoprotein whose role and mechanism in renal fibrosis remain incompletely elucidated. Therefor......

Magnesium reabsorption in the kidney

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 324 (3)

Mg2+ is essential for many cellular and physiological processes, including muscle contraction, neuronal activity, and metabo-lism. Consequently, the b......

Renal injury in relation to obesity and the additive effect of hypertension in female and male obese and lean ZSF1 rats

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2023; 325 (1)

Heart failure with preserved ejection fraction (HFpEF) is characterized by obesity, hypertension, diabetes mellitus, and chronic kidney disease. Obese......

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