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The neuropeptide substance P/neurokinin-1 receptor system and diabetes: From mechanism to therapy

期刊: BIOFACTORS, 2023; 49 (3)

Diabetes is a significant public health issue known as the world's fastest-growing disease condition. It is characterized by persistent hyperglycemia ......

Mechanisms of cancer cell death induction by triptolide

期刊: BIOFACTORS, 2023; 49 (4)

Drug resistance is a hot topic issue in cancer research and therapy. Although cancer therapy including radiotherapy and anti-cancer drugs can kill mal......

Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho-associated kinase pathway

期刊: BIOFACTORS, 2023; ()

This study evaluated possible mitigating effect of adropin on lung injury in diabetic rats, targeting role of Rho A/Rho-associated kinase pathway. Rat......

Taurine rescues pancreatic β-cell stress by stimulating α-cell transdifferentiation

期刊: BIOFACTORS, 2023; 49 (3)

The semi-essential ubiquitous amino acid taurine has been shown to alleviate obesity and hyperglycemia in humans; however, the pathways underlying the......

P38a contributes to TNF-a-induced IL-8 production in human gingival cells

期刊: BIOFACTORS, 2023; 49 (6)

Tumor necrosis factor-alpha (TNF-a) is a major inflammatory cytokine that induces interleukin (IL)-8 production. Although some studies have reported t......

Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease

期刊: BIOFACTORS, 2023; 49 (2)

Reports on a significant positive correlation between consumption of carotenoid-rich food and prevention of Alzheimer's disease (AD) led to the invest......

Interrelationships among platelet-activating factor and lipoprotein-associated phospholipase A2 activity and traditional cardiovascular risk factors

期刊: BIOFACTORS, 2023; 49 (2)

Traditionally cardiovascular disease (CVD) risk has been assessed through blood lipids and inflammatory marker C-reactive protein (hsCRP). Recent clin......

Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging

期刊: BIOFACTORS, 2023; 49 (3)

NRF2 is a master regulator of the cellular protection against oxidative damage in mammals and of multiple pathways relevant in the mammalian aging pro......

A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation

期刊: BIOFACTORS, 2023; ()

Lipid droplets (LDs) are organelles that store excess lipids and provide fatty acids for energy production during starvation. LDs are also essential f......

NRF2 in dermo-cosmetic: From scientific knowledge to skin care products

期刊: BIOFACTORS, 2023; 49 (1)

The skin is the organ that is most susceptible to the impact of the exposome. Located at the interface with the external environment, it protects inte......

Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP-2/-9 expression and activity

期刊: BIOFACTORS, 2023; 49 (2)

One kind of brain cancer with a dismal prognosis is called glioblastoma multiforme (GBM) due to its high growth rate and widespread tumor cell invasio......

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