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3-Iodothyronamine, a trace amine-associated receptor agonist, regulates intracellular Ca2+ increases via CaMK II through Epac2 in rat cerebral arterioles

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (5)

Trace amines (TAs) in the nervous system bind to TA-associated receptors (TAARs) and are involved in the regulation of monoaminergic functions. Among ......

Fractalkine's dual role in inflammation and hard tissue formation in cultured human dental pulp cells

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (6)

This study aimed to explore the potential roles of fractalkine/CX3CR1, primarily expressed in vascular endothelial cells and has recently been identif......

Validation of mitotic harvesting method with human cervical carcinoma HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators for radiation research

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (5)

The cell cycle is a series of events in the process of one cell giving rise to two daughter cells. The mitotic harvesting method, established by Teras......

Neonatal bilateral whisker trimming in male mice age-dependently alters brain neurotransmitter levels and causes adolescent onsets of social behavior abnormalities

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (4)

Tactile perception via whiskers is important in rodent behavior. Whisker trimming during the neonatal period affects mouse behaviors related to both w......

Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (5)

Myogenesis is required to generate skeletal muscle tissue and to maintain skeletal muscle mass. Decreased myogenesis under various pathogenic conditio......

The effect of the formalin-fixed paraffin-embedded process on salivary microbiota profiling

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (3)

In recent years, bacterial DNA in formalin-fixed paraffin-embedded (FFPE) samples has been recognized as a valuable bioresource for microbiota studies......

IL-33 deficiency suppresses alveolar bone loss in a ligature-induced periodontitis model

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (1)

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family that has been studied primarily in the context of type 2 immune responses. Recent repor......

Anatomical basis of gastrin- and CCK-secreting cells and their functions. A review

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (3)

Gastrin and CCK (cholecystokinin), gut hormones first secreted after postprandial stages, share the C-terminal amino acids and some types of receptors......

Impact of somatic mutations and transcriptomic alterations on cancer aneuploidy

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (5)

Aneuploidy has been recognized as one of hallmark of tumorigenesis since the early 20th century. Recent developments in structural variation analysis ......

Red foxtail millet upregulates brain- derived neurotrophic factor levels in vitro and in vivo

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (3)

Upregulation of the brain-derived neurotrophic factor (BDNF) in the brain can help in the prevention and treatment of depression. BDNF is synthesized ......

Comparative analysis of tumor content estimation methods based on simulated tumor samples identified their impact on somatic variant detection in cancer whole genome sequencing

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (4)

Whole genome sequencing (WGS) in cancer genomics has become widespread with recent technological innovations, and the amount and types of information ......

Immunohistochemical characterization of the mandibular condyle for type I and II collagen, aggrecan, MMP-9, and MMP-13 in MMP-2-deficient mice

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (2)

Mice devoid of matrix metalloproteinase (MMP)-2 due to gene targeting have been reported to show articular cartilage destruction in the knee joint; ho......

Role of aquaporin 5 and glandular blood flow in the acetylcholine-induced secretion of saliva in rats

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (2)

To clarify the role of the aquaporin 5 (AQP5) in salivary secretion, we evaluated acetylcholine (ACh)-induced secretion in Sprague-Dawley (SD) rats, r......

Acute effect of electrical stimulation on muscle protein synthesis and breakdown in the soleus muscle of hindlimb unloaded rats

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (5)

Electrical stimulation (ES) is effective for disuse-induced muscle atrophy. However, the acute effect of ES on muscle protein synthesis (MPS) and musc......

A point of view on human fat olfaction - do fatty derivatives serve as cues for awareness of dietary fats?

期刊: BIOMEDICAL RESEARCH-TOKYO, 2023; 44 (4)

Fat (triglycerides) consumption is critical for the survival of animals, including humans. Being able to smell fat can be advantageous in judging food......

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