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Influence of Gegenqinlian decoction on pharmacokinetics and pharmacodynamics of saxagliptin in type 2 diabetes mellitus rats

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (6)

Gegenqinlian decoction (GQD) is a classic prescription of traditional Chinese medicine (TCM), which originated from Shanghanlun. The combination of GQ......

Develop adult extrapolation to pediatrics and pediatric dose optimization based on the physiological pharmacokinetic model of azithromycin

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (3)

Physiologically-based pharmacokinetic (PBPK) models are more frequently used for supporting pediatric dose selection in small-molecule drugs. Through ......

Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (4)

The quantitative prediction of human pharmacokinetics (PK) including the PK profile and key PK parameters are critical for early drug development deci......

Predicting transporter mediated drug-drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where we are now and the way forward

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (3)

The greater utilization and acceptance of physiologically-based pharmacokinetic (PBPK) modeling to evaluate the potential metabolic drug-drug interact......

Selective inhibitory effects of suberosin on CYP1A2 in human liver microsomes

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (5)

Suberosin is a natural phytoconstituent isolated from Citropsis articulata, especially employed for its anticoagulant properties. Although metabolic s......

In vitro and ex vivo experimental models for evaluation of intranasal systemic drug delivery as well as direct nose-to-brain drug delivery

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (1)

The intranasal route of administration provides a noninvasive method to deliver drugs into the systemic circulation and/or directly into the brain. Di......

Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (5)

Certain pathological conditions, such as inflammation, are known to affect basal cytochrome P450 (CYP) expression by modulating transcriptional regula......

In-depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: PartI - Applications and rationale behind the use of open source-code software

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (3)

PBPK applications published in the literature support a greater adoption of non-open source-code (NOSC) software as opposed to open source-code (OSC) ......

Norvancomycin plasma concentration monitoring in hemodialysis patients with end stage kidney disease: A retrospective cohort study

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (2)

Blood concentration monitoring plays an important role in the rational use of norvancomycin. However, the reference interval for the norvancomycin pla......

Metabolism of testosterone and progesterone by cytochrome P450 2C19 allelic variants

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (6)

CYP2C19 is a member of the human microsomal cytochrome P450 (CYP). Significant variation in CYP2C19 levels and activity can be attributed to polymorph......

Association between α-defensin 5 and the expression and function of P-glycoprotein in differentiated intestinal Caco-2 cells

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (5)

alpha-Defensin 5 is known to be secreted by Paneth cells in the small intestine and plays an important role in eliminating pathogenic microorganisms. ......

Self-micellizing solid dispersion of tacrolimus: Physicochemical and pharmacokinetic characterization

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (6)

The present study was undertaken to develop a self-micellizing solid dispersion (SMSD) of tacrolimus (TAC) to improve the biopharmaceutical properties......

Integration of artificial neural network and physiologically based biopharmaceutic models in the development of sustained-release formulations

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (4)

Model-informed drug development is an important area recognized by regulatory authorities and is gaining increasing interest from the generic drug ind......

Enhanced oral bioavailability of capsaicin-loaded microencapsulation complex via electrospray technology: Preparation, in vitro and in vivo evaluation

期刊： BIOPHARMACEUTICS & DRUG DISPOSITION, 2023; 44 (2)

The purpose of this work was to fabricate the microencapsulation of capsaicin using electrospray technology and polyvinylpyrrolidone (PVP) K30 as a ca......

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