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Structure of the Useful Adaptive Result in the Systemic Organization of Physiological Functions as a Subject of Scientific Analysis: History and Prospects of Research

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; ()

The concept of useful adaptive result, a key concept in the theory of functional systems by P. K. Anokhin, is discussed. A large body of works devoted......

TFP5, a Peptide Derived from Cdk5 Activator p35, Protects Pancreatic β Cells from Glucose Toxicity

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 176 (1)

We studied the effect of TFP5 on MIN6 cells (cultured mouse islet beta cells) treated with different concentrations of glucose (5 or 25 mM). The resul......

Artificial COVID-19 T-Cell Immunogen

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; ()

An artificial T-cell immunogen consisting of conserved fragments of different proteins of the SARS-CoV-2 virus and its immunogenic properties were stu......

Anti-Atherosclerotic Action of a New Stimulator of Soluble Guanylate Cyclase in an Experiment

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 174 (3)

We studied the effect of an indolinone derivative GRS on the development of experimental atherosclerosis in C57BL/6 mice. Atherosclerosis was modeled ......

Laser Thermo-Photobiomodulation of Bone Marrow Mesenchymal Stem Cells

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 174 (4)

We studied the effect of laser radiation of moderate intensity with a wavelength of 970 nm on the efficiency of colony formation of rat bone marrow me......

Dynamics of the Levels of Interleukin 6, Its Soluble Receptor, and Soluble Glycoprotein 130 in Patients with Chronic Heart Failure and Preserved or Reduced Ejection Fraction

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 174 (5)

The features of IL-6 trans-signaling were studied in patients with heart failure with reduced (n=74) and preserved (n=31) ejection fraction (EF) durin......

To the Mechanism of the Antiarrhythmic Action of Compound ALM-802: the Role of Ryanodine Receptors

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 174 (6)

The effect of the compound N-1-(2,3,4-trimethoxy)-N-2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethane-diamine (code ALM-802) on the amplitude of t......

Modified Estrogen-Progesterone Induction Method of Mammary Gland Hyperplasia in Rats

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; ()

In female Wistar rats, mammary gland hyperplasia (MGH) was modeled according to a modified protocol involving estrogen-progesterone induction and taki......

The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; ()

Regulation of alternative splicing is carried out by RNA-binding proteins. Each alternative splicing event is controlled by several RNA-binding protei......

Methodology for Integral Study of Antagonistic Activity of Normal Nasal Microbiota to Select Potential Probiotics Efficient in Eradication of Staphylococcus aureus

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 175 (2)

The aim of this study was the development of a methodology for the integral study of the antagonistic activity of normal human microbiota against Stap......

The Role of Methylation of a Group of microRNA Genes in the Pathogenesis of Metastatic Renal Cell Carcinoma

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 175 (2)

The role of methylation of 9 miRNA genes in the pathogenesis of metastatic clear cell renal cell carcinoma was determined by quantitative methylation-......

The Role of cAMP-Dependent Intracellular Signaling Pathways in the Regulation of the Functions of Neural Stem Cells and Neuroglial Cells in Amyloid-β-Induced Neurodegeneration

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; ()

Under conditions of neurodegeneration modeled in vitro by the beta-amyloid peptide-(25-35) fragment (A beta 25-35), we studied the role of individual ......

Changes in Microcirculation in the Brain, Heart, and Liver in Female Rats with Translational Model of Alcoholic Cardiomyopathy

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; ()

We studied some features of blood and lymph microcirculation in the brain, heart, and liver of female rats with developed alcoholic cardiomyopathy. In......

Endogenous Regeneration of Alveolar Bone by Decellularized Tooth Matrix

期刊: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; ()

The efficiency of bone tissue regeneration by decellularized tooth matrix, demineralized tooth matrix, and commercial xenograft Bio-Oss Spongiosa was ......

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