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Real-World Safety and Effectiveness of Controlled-Release Cilostazol in Patients with Symptomatic Peripheral Artery Disease

期刊: CLINICAL DRUG INVESTIGATION, 2023; ()

Background Cilostazol is the only first-line medication for treating intermittent claudication, and the controlled-release (CR) formulation is associa......

Pharmacokinetics and Safety of Eptinezumab in Healthy Chinese Participants: A Randomized Clinical Trial

期刊: CLINICAL DRUG INVESTIGATION, 2023; 43 (11)

Background and ObjectiveMost evidence suggests that the pharmacokinetics of monoclonal antibodies (mAbs) are not meaningfully altered by patient chara......

A Phase I Study to Evaluate the Pharmacokinetic Drug.Drug Interaction of HP501, Febuxostat, and Colchicine in Male Chinese Patients with Hyperuricemia

期刊: CLINICAL DRUG INVESTIGATION, 2023; 43 (6)

Background and Objective HP501 is a highly selective renal urate transporter 1 (URAT1) inhibitor that is being developed for the treatment of hyperuri......

The Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, an Oral Small Molecule Factor XIa Inhibitor, in Healthy Chinese Volunteers

期刊: CLINICAL DRUG INVESTIGATION, 2023; 43 (6)

Background and ObjectiveThere is an unmet need for a safer anticoagulant since bleeding remains a concern with currently approved anticoagulants. Coag......

Efficacy and Safety of Switching from Sitagliptin to Ipragliflozin in Obese Japanese Patients with Type 2 Diabetes Mellitus: A Single-Arm Multicenter Interventional Study

期刊: CLINICAL DRUG INVESTIGATION, 2023; ()

Background Dipeptidyl peptidase-4 inhibitors have limited efficacy in improving glycemic control for obese Japanese patients with type 2 diabetes mell......

Safety Concerns with Nusinersen, Risdiplam, and Onasemnogene Abeparvovec in Spinal Muscular Atrophy: A Real-World Pharmacovigilance Study

期刊: CLINICAL DRUG INVESTIGATION, 2023; ()

Background and ObjectiveSpinal muscular atrophy (SMA) is a genetic disorder with limited treatment options. It is crucial to have a comprehensive unde......

Adherence to Adjuvant Endocrine Therapy and Survival Among Older Women with Early-Stage Hormone Receptor-Positive Breast Cancer

期刊: CLINICAL DRUG INVESTIGATION, 2023; 43 (3)

Background and ObjectiveAlthough improving adherence to adjuvant endocrine therapies (AETs) is critical to ensure better patient outcomes, the evidenc......

Assessing the Reporting of Harms in Systematic Reviews Focused on the Therapeutic and Cosmetic Uses of Botulinum Toxin

期刊: CLINICAL DRUG INVESTIGATION, 2023; 43 (2)

Background and Objective The expanding use of botulinum toxin (BoNT) in medical practice demonstrates the need to highlight whether there is adequate ......

Cost-Effectiveness Analysis of Atezolizumab versus Platinum-Based Chemotherapy as First-Line Treatment for Patients with Unresectable Advanced Non-small Cell Lung Cancer with PD-L1 Expression Status in Japan

期刊: CLINICAL DRUG INVESTIGATION, 2023; 43 (11)

Background and ObjectivesAtezolizumab has demonstrated safety and efficacy in patients with metastatic non-small cell lung cancer (NSCLC) in the IMpow......

Use of Acitretin Among Girls and Women of Childbearing Age and Occurrence of Acitretin-Exposed Pregnancies in Germany

期刊: CLINICAL DRUG INVESTIGATION, 2023; 43 (11)

Background and Objective Acitretin has long-lasting teratogenic properties. Therefore, pregnancies must be avoided during and within 3 years after aci......

Evaluation of the Drug-Drug Interaction Potential of Ensitrelvir Fumaric Acid with Cytochrome P450 3A Substrates in Healthy Japanese Adults

期刊: CLINICAL DRUG INVESTIGATION, 2023; 43 (5)

BackgroundManagement of drug-drug interactions (DDIs) for ensitrelvir, a novel 3-chymotrypsin-like protease inhibitor of SARS-CoV-2 infection is cruci......

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